6-[(E)-2-[4-(4-fluorophenyl)-6-phenyl-2-propan-2-ylpyridin-3-yl]ethenyl]-4-hydroxyoxan-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-[(E)-2-[4-(4-fluorophenyl)-6-phenyl-2-propan-2-ylpyridin-3-yl]ethenyl]-4-hydroxyoxan-2-one
• 化学式: C₂₇H₂₆FNO₃
• 分子量: 431.5
• InChiKey: LJIZUXQINHXGAO-OUKQBFOZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Multiparticulates of preferably an opioid, and method of manufacturing using extrusion
  申请人：EURO-CELTIQUE S.A.

  公开号：EP2269582A2

  公开（公告）日：2011-01-05

  Extrusion of a mix containing a pharmaceutically active agent can be achieved using a plasticising excipient in an amount sufficient to act as plasticiser and also act as lubricant, thereby avoiding the need for inclusion of a lubricant. The invention provides multiparticulates with controlled release properties, substantially free of lubricant.

  使用塑化辅料可实现含有药用活性剂的混合物的挤压，其用量足以用作增塑剂和润滑剂，从而避免了加入润滑剂的必要性。 本发明提供的多颗粒具有控释特性，基本上不含润滑剂。
• Multiparticulates
  申请人：Hayes Geoffrey Gerard

  公开号：US20080260815A1

  公开（公告）日：2008-10-23

  Extrusion of a mix containing a pharmaceutically active agent can be achieved using a plasticising excipient in an amount sufficient to act as plasticiser and also act as lubricant, thereby avoiding the need for inclusion of a lubricant. The invention provides multiparticulates with controlled release properties, substantially free of lubricant. The present invention is preferably directed to extruded multiparticulates containing an opioid such as oxycodone, an ammonium methacrylate copolymer such as Eudragit® RSPO, a plasticising excipient such as preferably stearyl alcohol and a water permeability modifier such as preferably Eudragit® RLPO. The obtained multiparticulates show a release rate profile which is pH-independent.
• US9259872B2
  申请人：——

  公开号：US9259872B2

  公开（公告）日：2016-02-16