S-3-N-乙酰基吡咯烷盐酸盐 | 1246277-44-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: S-3-N-乙酰基吡咯烷盐酸盐
• 英文名称: (S)-N-(pyrrolidin-3-yl)acetamide hydrochloride
• 英文别名: N-[(3S)-pyrrolidin-3-yl]acetamide hydrochloride；N-[(3S)-pyrrolidin-3-yl]acetamide;hydrochloride
• CAS: 1246277-44-0
• 化学式: C₆H₁₂N₂O*ClH
• 分子量: 164.635
• InChiKey: NVIYDYVCYFKVCW-RGMNGODLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.09
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  41.1
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  S-3-N-乙酰基吡咯烷盐酸盐 、 5-((5-((3'-(3-bromopropoxy)-2,6-dichloro-2'-methyl-[1,1'-biphenyl]-3-yl)methoxy)-4-chloro-2-(((1,3-dihydroxy-2-methylpropan-2-yl)amino)methyl)phenoxy)methyl)nicotinonitrile 在 N,N-二异丙基乙胺 作用下， 以 甲醇 为溶剂， 反应 5.0h， 以15.3 mg的产率得到N-((3S)-1-(3-((2',6'-dichloro-3'-((2-chloro-5-((5-cyanopyridin-3-yl)methoxy)-4-(((1,3-dihydroxy-2-methylpropan-2-yl)amino)methyl)phenoxy)methyl)-2-methyl-[1,1'-biphenyl]-3-yl)oxy)propyl)pyrrolidin-3-yl)acetamide
  参考文献：
  名称：

  COMPOUNDS USEFUL AS IMMUNOMODULATORS

  摘要：

  本发明公开一般涉及可用作免疫调节剂的化合物。本发明提供了化合物、包含此类化合物的组合物及其使用方法。本发明还涉及包含至少一种根据本发明的化合物的药物组合物，这些药物组合物可用于治疗各种疾病，包括癌症和传染病。

  公开号：

  US20170107202A1

文献信息

• Compounds useful as immunomodulators
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10745382B2

  公开（公告）日：2020-08-18

  The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

  本公开内容一般涉及可用作免疫调节剂的化合物。本文提供了化合物、包含此类化合物的组合物及其使用方法。本公开进一步涉及包含至少一种根据本公开的化合物的药物组合物，这些组合物可用于治疗各种疾病，包括癌症和传染性疾病。
• Pyrazolopyrimidines having activity against the respiratory syncytial virus (RSV)
  申请人：Janssen Sciences Ireland Unlimited Company

  公开号：US11339165B2

  公开（公告）日：2022-05-24

  The invention concerns compounds having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection. Formula (Ia).

  本发明涉及具有抗病毒活性的化合物，尤其是对呼吸道合胞病毒（RSV）的复制具有抑制活性的化合物。本发明还涉及包含这些化合物的药物组合物以及用于治疗呼吸道合胞病毒感染的化合物。式 (Ia).
• PYRAZOLOPYRIMIDINES HAVING ACTIVITY AGAINST THE RESPIRATORY SYNCYTIAL VIRUS (RSV)
  申请人：Janssen Sciences Ireland Unlimited Company

  公开号：US20200361942A1

  公开（公告）日：2020-11-19

  The invention concerns compounds having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection. Formula (Ia).
• [EN] CHEMICAL COMPOUNDS 831<br/>[FR] COMPOSÉS CHIMIQUES 831
  申请人：ASTRAZENECA AB

  公开号：WO2009016410A2

  公开（公告）日：2009-02-05

  The present invention relates to compounds of Formula (I) and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds provide a treatment for myeloproliferative disorders and cancer.
• [EN] COMPOUNDS USEFUL AS IMMUNOMODULATORS<br/>[FR] COMPOSÉS UTILES EN TANT QU'IMMUNOMODULATEURS
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2017066227A1

  公开（公告）日：2017-04-20

  The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases. The compounds have formula (I), wherein R2 is selected from (II) and (III).