1-(2-Bromo-1-(4-chlorophenyl)ethyl)-4-chlorobenzene | 121043-47-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-Bromo-1-(4-chlorophenyl)ethyl)-4-chlorobenzene
• 英文别名: 1-[2-bromo-1-(4-chlorophenyl)ethyl]-4-chlorobenzene
• CAS: 121043-47-8
• 化学式: C₁₄H₁₁BrCl₂
• 分子量: 330.0
• InChiKey: PEHQGSYXZOLXHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• Processes for the Preparation of 8-Chloro-1-Methyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine and Intermediates Related Thereto
  申请人：Weigl Ulrich

  公开号：US20090143576A1

  公开（公告）日：2009-06-04

  The present invention provides processes, methods and intermediates for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, salts, hydrates and crystal forms thereof which are useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.

  本发明提供了用于制备8-氯-1-甲基-2,3,4,5-四氢-1H-3-苯并哌啶、其盐、水合物和晶型的工艺、方法和中间体，这些物质可用作治疗中枢神经系统疾病（如肥胖症）的血清素（5-HT）受体激动剂。
• PROCESS FOR THE PREPARATION OF 8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE
  申请人：Arena Pharmaceuticals, Inc.

  公开号：EP2518053A1

  公开（公告）日：2012-10-31

  The present invention provides processes, methods and intermediates for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, salts, hydrates and crystal forms thereof which are useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.

  本发明提供了制备8-氯-1-甲基-2,3,4,5-四氢-1H-3-苯并氮平、盐、水合物及其晶体形式的过程、方法和中间体，其可用作治疗中枢神经系统疾病如肥胖症等的血清素（5-HT）受体激动剂。
• Process for the resolution of a mixture of (R)- and (S)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
  申请人：Arena Pharmaceuticals, Inc.

  公开号：EP2471779A1

  公开（公告）日：2012-07-04

  The present invention provides processes, methods and intermediates for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, salts, hydrates and crystal forms thereof which are useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.

  本发明提供了制备8-氯-1-甲基-2,3,4,5-四氢-1H-3-苯并哌啶、盐、水合物和晶体形式的过程、方法和中间体，它们可用作治疗中枢神经系统疾病如肥胖症的血清素（5-HT）受体激动剂。
• PROCESSES FOR THE PREPARATION OF 8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE AND INTERMEDIATES RELATED THERETO
  申请人：Arena Pharmaceuticals, Inc.

  公开号：EP2001852A2

  公开（公告）日：2008-12-17
• US8168782B2
  申请人：——

  公开号：US8168782B2

  公开（公告）日：2012-05-01