Amicarbalide isethionate | 3671-72-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Amicarbalide isethionate
• 英文别名: 1,3-bis(3-carbamimidoylphenyl)urea;2-hydroxyethanesulfonic acid
• CAS: 3671-72-5
• 化学式: C17H22N6O5S
• 分子量: 422.5
• InChiKey: ULIMEAUEIJDDSD-UHFFFAOYSA-N

物化性质

• 熔点：
  209° (decomp 256°)

计算性质

• 辛醇/水分配系数(LogP)：
  0.77
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  224
• 氢给体数：
  8
• 氢受体数：
  7

文献信息

• Hydrogels
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0067671A2

  公开（公告）日：1982-12-22

  A hydrogel which comprises polymerised moieties derivable from (i) at least one polymerisable cyclic (thio)ether and (ii) at least one hydrophilic homo- or copolymer.

  一种水凝胶，包含可由 (i) 至少一种可聚合环（硫）醚和 (ii) 至少一种亲水均聚物或共聚物衍生的聚合分子。
• Compositions comprising encapsulated particles
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0076158A2

  公开（公告）日：1983-04-06

  A composition which comprises at least one solid or liquid particle comprising at least one active substance, the or a plurality of such particles being encapsulated by the in situ cationic (co)polymerisation thereon of at least one cationically polymerisable monomer or prepolymer.

  一种组合物，它包括至少一种含有至少一种活性物质的固体或液体微粒，这些微粒或多个微粒被至少一种可阳离子聚合的单体或预聚合体原位阳离子（共）聚合包裹。
• Sustained release compositions
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0076636A1

  公开（公告）日：1983-04-13

  A non-crosslinked derivative formable by reacting at least one substituted or unsubstituted, saturated or unsaturated, mono-, di- or poly-carboxy, hydroxy or mercapto hydrocarbon with at least one cyclic unsaturated (thio)ether.

  至少一种取代或未取代、饱和或不饱和、单羧基、二羧基或多羧基、羟基或巯基碳氢化合物与 至少一种环状不饱和（硫）醚反应而形成的非交联衍生物。
• Controlled release device
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0132384A2

  公开（公告）日：1985-01-30

  A controlled release device which comprises: (i) a hydrogel; and incorporated therewith (ii) an active substance, at least part of at least one surface of the device comprising (iii) a layer which is impermeable to aqueous media.

  一种控释装置，包括 (i) 水凝胶；并与之结合 (ii) 一种活性物质、 (iii) 不透水介质层。
• Dispensing device
  申请人：BRITISH TECHNOLOGY GROUP LIMITED

  公开号：EP0384646A1

  公开（公告）日：1990-08-29

  Novel devices for the controlled release of active materials especially pharmaceutical are formed from at least two interpenetrating pieces. The male piece is water swellable and swells to disengage the female piece. The female piece is preferably formed from a thermoplastic, e.g. LDPE or from a soluble material such as gelatin which is rendered impermeable by an external coating of a hydrophobic material such as PVC. The devices find particular application as oral dosage forms for use in man.

  用于控制活性物质（尤其是药物）释放的新型装置由至少两个相互渗透的部件组成。公件可遇水膨胀，膨胀后可脱离母件。母片最好由热塑性塑料（如低密度聚乙烯）或可溶性材料（如明胶）制成，通过在母片外部涂上一层疏水性材料（如聚氯乙烯）使其具有防渗透性。这种装置特别适用于人的口服剂型。