Spiro(1,3-benzodioxole-2,1'-cyclohexane), 5-methyl- | 51047-34-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: Spiro(1,3-benzodioxole-2,1'-cyclohexane), 5-methyl-
• 英文别名: 5-methylspiro[1,3-benzodioxole-2,1'-cyclohexane]
• CAS: 51047-34-8
• 化学式: C₁₃H₁₆O₂
• 分子量: 204.26
• InChiKey: SKKYCLWBJFSQFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY
  申请人：Li Hui

  公开号：US20100190770A1

  公开（公告）日：2010-07-29

  Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.

  公开了化合物I的结构，含有这些化合物的组合物，以及在治疗需要调节JAK途径或抑制JAK激酶，特别是JAK 2和JAK3的情况下使用这些化合物和组合物的方法。
• Compositions and methods for inhibition of the JAK pathway
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US10005767B2

  公开（公告）日：2018-06-26

  Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.

  本文公开了式 I 的化合物、含有这些化合物的组合物，以及这些化合物和组合物用于治疗调节 JAK 通路或抑制 JAK 激酶（尤其是 JAK 2 和 JAK3）具有治疗作用的疾病的方法。
• USE OF IMIDAZO[2,1-b]-1,3,4-THIADIAZOLE-2-SULFONAMIDE COMPOUNDS TO TREAT NEUROPATHIC PAIN
  申请人：Durkin Jon

  公开号：US20090170845A1

  公开（公告）日：2009-07-02

  Disclosed herein are methods and compositions for treating and/or prophylaxis of neuropathic pain in a subject. The methods comprise administering to the subject suffering from neuropathic pain, a therapeutically effective amount of a compound, according to Formula I: or a salt thereof, wherein A, R 5 and R 6 are defined herein.
• Compositions and Methods for Treatment of Cardiovascular Disease
  申请人：Rajagopal Desikan

  公开号：US20120129818A1

  公开（公告）日：2012-05-24

  Ortho methoxy phenolic compounds are provided that include methylenedioxyphenyl ferulate and ferulylproline and derivatives thereof. Pharmaceutical compositions comprising the compounds and methods of using the compounds for treating cardiovascular diseases, including hypertension, atherosclerosis, coronary heart disease, angina, stroke, and myocardial infarction, are further provided. The compounds are also useful in reducing low-density lipoprotein oxidation, improving or increasing vasodilation, and reducing plaque destabilization in a subject.
• RESIN, RESIST COMPOSITION AND METHOD FOR PRODUCING RESIST PATTERN, AND COMPOUND
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20210191266A1

  公开（公告）日：2021-06-24

  Disclosed are a resin comprising a structural unit represented by formula (I), and a structural unit represented by formula (a1-1) and/or a structural unit represented by formula (a1-2), and a resist composition including this resin: