Carbamic acid, (3,5-dichlorophenyl)- | 105687-75-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Carbamic acid, (3,5-dichlorophenyl)-
• 英文别名: (3,5-dichlorophenyl)carbamic acid
• CAS: 105687-75-0
• 化学式: C₇H₅Cl₂NO₂
• 分子量: 206.02
• InChiKey: OMJLGCDQPXRIHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS<br/>[FR] COMPOSES 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE POUR LE TRAITEMENT DE LA TUBERCULOSE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2005042542A1

  公开（公告）日：2005-05-12

  The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1)in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and -(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30)and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.

  本发明提供了一种由以下一般式表示的2,3-二氢-6-硝基咪唑[2,1-b]噁唑化合物：(1)在上述式(1)中，R1代表氢原子或C1-C6烷基，n代表0至6的整数，R1和-(CH2)nR2可以与下面的式(30)一起形成一个螺环，与相邻的碳原子一起（在下面的式中，RRR代表可能在哌啶环上具有取代基的哌啶基），(30)和R2代表苯并噻唑氧基、喹啉氧基、吡啶氧基或类似物。该化合物对结核分枝杆菌、多药耐药结核分枝杆菌和非典型耐酸细菌具有出色的杀菌作用。
• 2,3-Dihydro-6-Nitroimidazo (2,1-b) Oxazole Compounds for the Treatment of Tuberculosis
  申请人：Tsubouchi Hidetsugu

  公开号：US20080119478A1

  公开（公告）日：2008-05-22

  The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1) in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and —(CH2) n R2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30) and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis , multi-drug-resistant Mycobacterium tuberculosis , and atypical acid-fast bacteria.

  本发明提供了一种由下述通式（1）表示的2,3-二氢-6-硝基咪唑[2,1-b]噁唑化合物： 在上述式（1）中，R1代表氢原子或C1-C6烷基，n代表0到6的整数，R1和—(CH2)nR2可以与相邻的碳原子形成如下式（30）所示的螺环，其中，在下式中，RRR代表可能在哌啶环上具有取代基的哌啶基： （30）且R2代表苯并噻唑氧基、喹啉氧基、吡啶氧基或类似基团。该化合物对结核分枝杆菌、多重耐药结核分枝杆菌和非典型酸杆菌具有优异的杀菌作用。
• Heterocyclic compounds
  申请人：JOHN WYETH & BROTHER LIMITED

  公开号：EP0361629A2

  公开（公告）日：1990-04-04

  Aryl ureas and carbamic acid derivatives of formula A-NHCW-Y-B and pharmaceutically acceptable salts thereof wherein A is a specified aromatic radical including 3,5-dichlorophenyl W is O or S Y is NH or S and B is a specified saturated azacyclic ring, eg tropan-3-yl or quinuclidin-3-yl, possess 5-HT₃-antagonistic activity and are, for example, useful in treatment of migraine, emesis, anxiety, gastro-intestinal disorders and as anti-psychotics.

  式中的芳基脲和氨基甲酸衍生物 A-NHCW-Y-B 及其药学上可接受的盐类 其中 A 是特定的芳香基，包括 3,5-二氯苯基 W是O或S Y 是 NH 或 S 和 B 是特定的饱和氮杂环，例如托烷-3-基或喹啉-3-基、 具有 5-HT₃拮抗活性，可用于治疗偏头痛、呕吐、焦虑、胃肠道疾病和抗精神病药等。
• NOVEL POLYSACCHARIDE DRIVATIVE AND SEPARATING AGENT
  申请人：DAICEL CHEMICAL INDUSTRIES, LTD.

  公开号：EP0527235A1

  公开（公告）日：1993-02-17

  A compound prepared by chemically bonding at least one hydroxyl group of the 2-, 3- and 6-hydroxyl groups of a cyclic oligosaccharide derivative to a carrier through a spacer (except one wherein the 6-hydroxyl group is bonded to a carrier through an ether linkage), and a separating agent and a separator both containing the above compound which are remarkably useful as a functional material for optical resolution.

  将环状寡糖衍生物的 2-、3-和 6-羟基中的至少一个羟基通过间隔物与载体化学键合而制备的化合物（6-羟基通过醚键与载体键合的化合物除外），以及含有上述化合物的分离剂和分离器，作为光学分辨功能材料具有显著的用途。
• SEPARATORY AGENT FOR OPTICAL ISOMER
  申请人：Daicel Chemical Industries, Ltd.

  公开号：EP1422521A1

  公开（公告）日：2004-05-26

  Provided is a separating agent for enantiomeric isomers, that is advantageous from the production standpoints of having high enantiomeric resolution ability inherent in polysaccharide derivatives, solvent resistance, high solubility in a reaction solvent, andgoodfiltrationproperty. Thatis, the separating agent for enantiomeric isomers includes a polysaccharide oligomer derivative derived from a polysaccharide oligomer having a number-average degree of polymerization of from 5 to less than 50, supported on a carrier.

  本发明提供了一种对映体异构体分离剂，从多糖衍生物固有的高对映体解析能力、耐溶剂性、在反应溶剂中的高溶解度以及良好的过滤性能等生产角度来看，该分离剂具有优势。也就是说，对映体异构体分离剂包括一种多糖低聚物衍生物，该衍生物来源于一种多糖低聚物，该多糖低聚物的平均聚合度为 5 至小于 50，支撑在载体上。