2-chloro-N-(5-methyl-1,2-oxazol-3-yl)-5-nitrobenzamide | 313223-89-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-N-(5-methyl-1,2-oxazol-3-yl)-5-nitrobenzamide
• CAS: 313223-89-1
• 化学式: C11H8ClN3O4
• mdl: MFCD00805639
• 分子量: 281.65
• InChiKey: DNMZREGGPLYTCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Fat accumulation-modulating compounds
  申请人：AdipoGenix, Inc.

  公开号：US20030130343A1

  公开（公告）日：2003-07-10

  The present invention pertains to compounds effective at modulating fatty acid or triglyceride accumulation by fat cells, such compounds having therapeutic potential as regulators of body mass and for the treatment of overweight individuals, obesity, and metabolic disorders. Featured compounds are those having the structure set forth and exemplified herein: 1 wherein Ar is a substituted or unsubstituted phenyl group; R is a hydrogen or C 1-6 alkyl group; and P is a substituted or unsubstituted nitrogen-containing heteroaryl group; said compound having the property of modulating the accumulation of fatty acids by cells. Therapeutic methods and pharmaceutical compositions featuring these compounds are also provided.

  本发明涉及能有效调节脂肪细胞的脂肪酸或甘油三酯积累的化合物，此类化合物具有调节体重和治疗超重者、肥胖症和代谢紊乱的治疗潜力。特选化合物是指具有本文所述和举例说明的结构的化合物： 1 其中 Ar 是取代或未取代的苯基；R 是氢或 C 1-6 烷基；以及 P 是取代或未取代的含氮杂芳基；所述化合物具有调节细胞脂肪酸积累的特性。还提供了以这些化合物为特征的治疗方法和药物组合物。
• [EN] FAT ACCUMULATION-MODULATING COMPOUNDS<br/>[FR] COMPOSES SERVANT A MODULER L'ACCUMULATION DES GRAISSES
  申请人：ADIPOGENIX INC

  公开号：WO2003013516A1

  公开（公告）日：2003-02-20

  The present invention pertains to compounds effective at modulating fatty acid or triglyceride accumulation by fat cells, such compounds having therapeutic potential as regulators of body mass and for the treatment of overweight individuals, obesity, and metabolic disorders. Featured compounds are those having the structure set forth and exemplified herein: Formula (I) wherein Ar is a substituted or unsubstituted phenyl group; R is a hydrogen or C1-6 alkyl group; and P is a substituted or unsubstituted nitrogen-containing heteroaryl group; said compound having the property of modulating the accumulation of fatty acids by cells. Therapeutic methods and pharmaceutical compositions featuring these compounds are also provided.