4-methyl-N-(pyridin-3-ylmethyl)aniline | 113248-79-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-N-(pyridin-3-ylmethyl)aniline
• CAS: 113248-79-6
• 化学式: C₁₃H₁₄N₂
• 分子量: 198.268
• InChiKey: BBZDHSKNNFBFKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-methyl-N-(pyridin-3-ylmethyl)aniline 、 甲基磺酰氯 生成 N-(4-methylphenyl)-N-(pyridin-3-ylmethyl)methanesulfonamide
  参考文献：
  名称：

  KRUMKALNS, ERIKA V.;SMILEY, DAVID L.

  摘要：

  DOI：
• 作为产物：
  描述：

  3-<(4-methylphenyl)iminomethyl>pyridine 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 生成 4-methyl-N-(pyridin-3-ylmethyl)aniline
  参考文献：
  名称：

  Sulfonic acid supported on hydroxyapatite-encapsulated-γ-Fe2O3 nanocrystallites as a magnetically separable catalyst for one-pot reductive amination of carbonyl compounds

  摘要：

  开发了一种新的环境友好型方法，通过室温下在一锅法反应中使用硼氢化钠还原胺化羰基化合物，结合磁性可回收的磺酸基团负载于羟基磷灰石包覆的γ-Fe2O3（γ-Fe2O3@HAP-SO3H）来制备二级或三级胺。催化剂可通过外加磁场轻松从反应混合物中分离，并可重复使用六次而不会显著降低催化活性。

  DOI：

  10.1039/c1gc15470b

文献信息

• Simple electrochemical reduction of nitrones to amines
  作者：Eduardo Rodrigo、Siegfried R. Waldvogel

  DOI：10.1039/c8sc04337j

  日期：——

  rings to the corresponding amines. The main advantage of this protocol relies on the fact that only electrons are needed, avoiding the use of different chemicals and harsh procedures, something that reinforces some green aspects. The conversion tolerates different moieties and a large variety of functional groups. In addition, this electrolysis can be performed on a simple undivided beaker-type cell

  电力的使用允许将含有芳族和杂芳族环的硝酮还原为相应的胺。该协议的主要优点在于，只需要电子，就可以避免使用不同的化学药品和苛刻的程序，从而增强了某些绿色方面。该转化耐受不同的部分和各种各样的官能团。另外，该电解可以在恒定电流条件下在简单的未分开的烧杯型电池上进行。
• Agriculturally useful sulfonamides
  申请人：Eli Lilly and Company

  公开号：US04874775A1

  公开（公告）日：1989-10-17

  A series of novel N-pyrinidyl- and pyrimidinyl sulfonamides are useful as fungicides and herbicides particularly for the protection of plants from phytopathogens.

  一系列新型的N-吡啶基和嘧啶基磺酰胺可用作杀菌剂和除草剂，特别适用于保护植物免受植物病原体的侵害。
• Agriculturally-useful sulfonamides
  申请人：ELI LILLY AND COMPANY

  公开号：EP0206581A2

  公开（公告）日：1986-12-30

  @ A series of novel N-pyridinyl- and pyrinidinyl sulfonamides are useful as fungicides and herbicides. These compounds are particularly useful for the protection of plants from phytopathogens.

  一系列新型 N-吡啶基和吡啶基磺酰胺可用作杀真菌剂和除草剂。 这些化合物尤其有助于保护植物免受植物病原体的侵害。
• Substituted 8-heteroaryl xanthines
  申请人：Adenosine Therapeutics, LLC

  公开号：EP2295434A2

  公开（公告）日：2011-03-16

  The present invention provides compounds and pharmaceutical compositions that are selective antagonists of A2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.

  本发明提供了作为 A2B 腺苷受体（ARs）选择性拮抗剂的化合物和药物组合物。这些化合物和组合物可用作药剂。
• 1,4 disubstituted 3 cyano pyridone derivatives and their use as positive allosteric modulators of mGluR2 receptors
  申请人：Ortho-McNeil-Janssen Pharmaceuticals, Inc.

  公开号：EP2426125A1

  公开（公告）日：2012-03-07

  The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors - subtype 2 ("mGluR2") which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

  本发明涉及新型化合物，特别是符合式 (I) 的新型吡啶酮衍生物 其中所有基团在申请和权利要求中均有定义。根据本发明的化合物是代谢受体-亚型 2（"mGluR2"）的正异位调节剂，可用于治疗或预防与谷氨酸功能障碍相关的神经和精神疾病以及涉及代谢受体的 mGluR2 亚型的疾病。特别是，这类疾病是选自焦虑症、精神分裂症、偏头痛、抑郁症和癫痫组的中枢神经系统疾病。本发明还涉及药物组合物和制备此类化合物及组合物的工艺，以及使用此类化合物预防和治疗涉及 mGluR2 的此类疾病。