N-[5-(1,3-benzothiazol-2-yl)-2-methylphenyl]-4-fluorobenzamide | 5684-92-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[5-(1,3-benzothiazol-2-yl)-2-methylphenyl]-4-fluorobenzamide
• CAS: 5684-92-4
• 化学式: C₂₁H₁₅FN₂OS
• 分子量: 362.4
• InChiKey: GGCOTUPURRDBCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Treatment and Prevention of Dengue Virus Infections
  申请人：Byrd Chelsea M.

  公开号：US20120258079A1

  公开（公告）日：2012-10-11

  Methods and pharmaceutical compositions for treating viral infections, by administering certain 2 -aryl-benzothiazole or 2 -heteroaryl-benzothiazole derivative compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
• TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS
  申请人：SIGA TECHNOLOGIES, INC.

  公开号：US20150150852A1

  公开（公告）日：2015-06-04

  Methods and pharmaceutical compositions for treating viral infections, by administering certain 2-aryl-benzothiazole or 2-heteroaryl-benzothiazole derivative compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
• US8993604B2
  申请人：——

  公开号：US8993604B2

  公开（公告）日：2015-03-31
• [EN] TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS<br/>[FR] TRAITEMENT ET PRÉVENTION D'INFECTIONS PAR LE VIRUS DE LA DENGUE
  申请人：SIGA TECHNOLOGIES INC

  公开号：WO2011002635A1

  公开（公告）日：2011-01-06

  Methods and pharmaceutical compositions for treating viral infections, by administering certain 2-aryl-benzothiazole or 2-heteroaryl-benzothiazole derivative compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.