Carbamodithioic acid, dipentyl- | 99-70-7

• 分子结构分类: 有机化合物 - 有机硫化合物
• 英文名称: Carbamodithioic acid, dipentyl-
• 英文别名: dipentylcarbamodithioic acid
• CAS: 99-70-7
• 化学式: C₁₁H₂₃NS₂
• 分子量: 233.4
• InChiKey: JWHFYIKVRLMUCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  36.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Process for producing bismuth dithiocarbamates and dithiophosphorates
  申请人：——

  公开号：US20020183534A1

  公开（公告）日：2002-12-05

  A process for producing a bismuth dithiocarbamate or dithiophosphorate by the reaction of a bismuth hydroxide, bismuth oxide or bismuth oxynitrate with a dithiocarbamate or a dithiophosphoric acid. The bismuth dithiocarbamates and dithiophosphorates exhibit very good EP and antiwear properties and are useful in lubricant formulations.

  一种通过将氢氧化铋、氧化铋或硝酸氧铋与二硫代氨基甲酸盐或二硫代磷酸反应来生产二硫代氨基甲酸铋或二硫代磷酸铋的方法。二硫代氨基甲酸铋和二硫代磷酸铋展现出非常好的极压和抗磨性能，并且在润滑剂配方中非常有用。
• [EN] COMPOSITIONS COMPRISING A METAL SOURCE, DITHIOCARBAMATE AND CYCLODEXTRIN<br/>[FR] COMPOSITIONS COMPRENANT UNE SOURCE MÉTALLIQUE, UN DITHIOCARBAMATE ET UNE CYCLODEXTRINE
  申请人：DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTS

  公开号：WO2018069525A1

  公开（公告）日：2018-04-19

  The present invention provides a novel class of dithiocarbamate-metal complexes and their uses in medicine. Also provided by the invention are combinations and pharmaceutical compositions, comprising a dithiocarbamate (or thiuram disulphide) such as disulfiram and cyclodextrin, with a source of a heavy metal. Surprisingly, the inventors found a synergistic potentiation of the anti-tumor effect, when a dithiocarbamate/heavy metal mixture was combined with a cyclodextrin. The compounds and combination of the invention are particularly useful in the treatment of tumor diseases, and other disorders. Provided are the compounds, combination, pharmaceutical compositions and kits, as well as methods for the preparation of the combinations of the invention.

  本发明提供了一种新型的二硫代氨基甲酸盐金属络合物及其在医学中的用途。该发明还提供了一种组合物和药物组合物，包括二硫代氨基甲酸盐（或硫代硫酰二乙基）如二硫代硫酸铜和环糊精，以及一种重金属的来源。令人惊讶的是，发明人发现当将二硫代氨基甲酸盐/重金属混合物与环糊精结合时，抗肿瘤效果呈现协同增强作用。本发明的化合物和组合物在肿瘤疾病和其他疾病的治疗中特别有用。提供了本发明的化合物、组合物、药物组合物和试剂盒，以及制备本发明组合物的方法。
• IMPROVED DITHIOCARMABATE BASED COMPOUNDS, THERAPIES AND DIAGNOSTICS
  申请人：Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts

  公开号：EP3693740A1

  公开（公告）日：2020-08-12

  The present invention provides an improved class of dithiocarbamate complexes with increased tumour spheroid activity. The invention provides the novel compounds as such, and their medical application for the treatment of tumour diseases. The compounds of the invention are surprisingly effective compared to the prior art dithiocarbamates, in particular with respect to tumour spheroids. Another aspect of the herein described invention provides a diagnostic determination of tumours with increased susceptibility to a treatment with the dithiocarbamates of the invention. This aspect of the invention suggests determining components of the thioredoxin 1 (TRX1)/thioredoxin reductase 1 (TRXR1) system as an indicator of treatment responders. In context of this inventive aspect, the dithiocarbamate compounds of the invention were identified as competitive TRXR1 binders, and hence, the TRX1-amount in tumours is an important factor for treatment success.

  本发明提供了一类改进的二硫代氨基甲酸酯配合物，具有增强的肿瘤球活性。该发明提供了这些新化合物本身，以及它们在治疗肿瘤疾病方面的医学应用。与先前技术中的二硫代氨基甲酸酯相比，本发明的化合物在肿瘤球方面表现出惊人的有效性。本发明描述的另一个方面提供了一种诊断确定对本发明的二硫代氨基甲酸酯治疗具有增加敏感性的肿瘤的方法。该发明的这一方面建议确定硫氧还蛋白1（TRX1）/硫氧还蛋白还原酶1（TRXR1）系统的组分作为治疗反应者的指标。在这一创新方面的背景下，本发明的二硫代氨基甲酸酯化合物被确定为竞争性TRXR1结合物，因此，肿瘤中TRX1的含量是治疗成功的重要因素。
• GOLD(I) COMPLEXES WITH ANTICANCER PROPERTIES AND METHODS OF USE THEREOF
  申请人：KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

  公开号：US20170197997A1

  公开（公告）日：2017-07-13

  Monomeric and dimeric gold(I) complexes as anticancer agents. The gold(I) complexes are coordinated to mixed ligands: one phosphine-based ligand that may be monodentate or bidentate and at least one dithiocarbamate-based ligand that is monodentate. Pharmaceutical compositions incorporating the gold(I) complexes, methods of synthesis, methods of treating cancer and methods of inhibiting cancer cell proliferation and inducing cancer cell apoptosis are also provided.

  单聚和双聚金(I)配合物作为抗癌剂。金(I)配合物与混合配体配位：一个基于膦的配体，可能是一齿或二齿，以及至少一个基于二硫代氨基甲酸盐的一齿配体。还提供了含有金(I)配合物的制药组合物、合成方法、治疗癌症的方法、抑制癌细胞增殖的方法和诱导癌细胞凋亡的方法。
• LUBRICANT COMPOSITIONS CONTAINING A HETEROAROMATIC COMPOUND
  申请人：MATHUR Naresh

  公开号：US20120291737A1

  公开（公告）日：2012-11-22

  An ashless additive for lubricating oil compositions, lubricating oil compositions and methods for lubricating that are effective to improve the total base number (TBN) of a lubricant composition. The additive is a reaction product of a compound of the formula: with NH 3 , an alcohol, an amine, or a hydrocarbyl amine, wherein R 1 is selected from H, a hydrocarbyl group, the alcohol or amine contains from 1 to about 24 carbon atoms, and the hydrocarbyl amine has a number average molecular weight ranging from about 100 to about 6000

  一种无灰添加剂，用于润滑油组合物，润滑油组合物和润滑方法，能够有效地提高润滑剂组合物的总碱值（TBN）。该添加剂是以下化合物与NH3、醇、胺或烃基胺的反应产物：其中R1选自H、烃基基团，醇或胺含有1至约24个碳原子，烃基胺的数均分子量范围从约100到约6000。