(+)-p-Chloroamphetamine hydrochloride | 16064-30-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (+)-p-Chloroamphetamine hydrochloride
• 英文别名: (2S)-1-(4-chlorophenyl)propan-2-amine;hydrochloride
• CAS: 16064-30-5
• 化学式: C9H13Cl2N
• 分子量: 206.11
• InChiKey: DZAANUYJOGCNLL-FJXQXJEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.65
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• [EN] METHODS AND COMPOSITIONS FOR PREPARATION OF AMPHETAMINE CONJUGATES AND SALTS THEREOF<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LA PRÉPARATION DE CONJUGUÉS D'AMPHÉTAMINE ET DE SELS DE CEUX-CI
  申请人：CAMBREX CHARLES CITY INC

  公开号：WO2010148305A1

  公开（公告）日：2010-12-23

  The invention provides methods and compositions for preparing amphetamine conjugates, such as lisdexamfetamine, homoarginine-D-amphetamine, and salts thereof. In one embodiment, the invention provides methods of preparing an amphetamine conjugate from a chloramphetamine intermediate.

  这项发明提供了制备苯丙胺共轭物的方法和组合物，例如利斯达氯安非他明、同型精氨酸-D-苯丙胺及其盐。在一个实施例中，该发明提供了从氯苯丙胺中间体制备苯丙胺共轭物的方法。
• METHOD OF MAKING AMPHETAMINE
  申请人：Buenger Greg

  公开号：US20090292143A1

  公开（公告）日：2009-11-26

  A method in which a crude chlorinated product of a phenylpropanolamine, preferably prepared by reacting thionyl chloride with the phenylpropanolamine, is purified by contacting an aqueous solution of the crude product with carbon. The carbon-treated solution of the crude chlorinated product of a phenylpropanolamine is catalytically hydrogenated to the corresponding amphetamine derivative.

  一种方法，通过将苯丙醇胺与亚砜氯反应制备粗氯化产物，然后通过将粗产品的水溶液与活性炭接触来纯化。经活性炭处理的苯丙醇胺粗氯化产物的溶液被催化氢化成相应的苯丙胺衍生物。
• PROCESS FOR THE PREPARATION OF LISDEXAMFETAMINE AND RELATED DERIVATIVES
  申请人：NORAMCO, INC.

  公开号：US20160376618A1

  公开（公告）日：2016-12-29

  The present invention is directed to processes for the preparation of lisdexamfetamine and related derivatives, wherein the processes comprise coupling to racemic or enantiomerically enriched amphetamine and wherein the resulting product is advantageously enantiomerically or diastereomerically enriched in the desired stereoisomer.

  本发明涉及制备利斯达洛非甲胺及相关衍生物的过程，其中该过程包括与外消旋或旋光异构富集的苯丙胺偶联，并且所得产物有优势地在所需立体异构体方面富集旋光异构体或二对映异构体。
• [EN] PROCESS FOR THE PREPARATION OF LISDEXAMFETAMINE AND RELATED DERIVATIVES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE LISDEXAMFÉTAMINE ET DE DÉRIVÉS ASSOCIÉS
  申请人：NORAMCO INC

  公开号：WO2017003721A1

  公开（公告）日：2017-01-05

  The present invention is directed to processes for the preparation of lisdexamfetamine and related derivatives, wherein the processes comprise coupling to racemic or enantiomerically enriched amphetamine and wherein the resulting product is advantageously enantiomerically or diastereomerically enriched in the desired stereoisomer.

  本发明涉及制备利斯达克赛非及其相关衍生物的过程，其中该过程包括与外消旋或对映富集的苯丙胺偶联，所得产物在所需立体异构体方面具有有利的对映异构体或二对映异构体富集。
• Process for the preparation of lisdexamfetamine and related derivatives
  申请人：NORAMCO, INC.

  公开号：US10544434B2

  公开（公告）日：2020-01-28

  The present invention is directed to processes for the preparation of lisdexamfetamine and related derivatives, wherein the processes comprise coupling to racemic or enantiomerically enriched amphetamine and wherein the resulting product is advantageously enantiomerically or diastereomerically enriched in the desired stereoisomer.

  本发明涉及制备利司他明及相关衍生物的工艺，其中包括与外消旋或对映体富集的安非他明偶联，所得产物有利地富集了所需立体异构体的对映体或非对映体。