3,4,5-Tribromosalicylanilide | 24556-65-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4,5-Tribromosalicylanilide
• 英文别名: 3,4,5-tribromo-2-hydroxy-N-phenylbenzamide
• CAS: 24556-65-8
• 化学式: C₁₃H₈Br₃NO₂
• 分子量: 449.92
• InChiKey: WLYIIDKKPCXCLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

ADMET

毒理性

• 副作用

Dermatotoxin - PACD (photoallergic contact dermatitis). 皮肤毒素 - 光变态性接触性皮炎。

Dermatotoxin - PACD (photoallergic contact dermatitis).

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

文献信息

• Peptide deformylase activated prodrugs
  申请人：——

  公开号：US20030091587A1

  公开（公告）日：2003-05-15

  This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting the microorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gram-negative microorganism, e.g., S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, E. cloacae, M. catarrhalis, E. coli, E. faecalis, H. influenzae and P. aeruginosa . This method can be practiced in vitro, ex vivo and in vivo. Further provided is a method for alleviating the symptoms of an infection by a Peptide Deformylase expressing microorganism in a subject by administering or delivering to the subject an effective amount of the compound described above.

  本发明提供了一种通过接触微生物与本文所述化合物的有效量来抑制表达肽变形酶的微生物生长的方法。该方法可以抑制革兰氏阳性和革兰氏阴性微生物的生长，例如金黄色葡萄球菌、表皮葡萄球菌、肺炎克雷伯菌、空气发酵肠杆菌、克洛伊氏肠杆菌、痰液产生的杆菌、大肠杆菌、嗜肠球菌、流感嗜血杆菌和铜绿假单胞菌。该方法可以在体外、体外和体内实施。此外，本发明还提供了一种通过向受试者施用或输送上述化合物的有效量来减轻表达肽变形酶的微生物感染症状的方法。
• Methods for identifying therapeutic targets for treating infectious disease
  申请人：——

  公开号：US20030130179A1

  公开（公告）日：2003-07-10

  This invention provides methods and systems to identify enzymes that act as enzyme catalyzed therapeutic activators and the enzymes identified by these methods. Also provided by this invention are compounds activated by the enzymes as well as compositions containing these compounds.

  本发明提供了一种识别作为酶催化治疗活化剂的酶的方法和系统，以及通过这些方法识别的酶。本发明还提供了被这些酶激活的化合物以及含有这些化合物的组合物。
• Cleansing bar compositions comprising a high level of water
  申请人：Salvador Reyes Charlie

  公开号：US20080020959A1

  公开（公告）日：2008-01-24

  Cleansing bar compositions having high water content comprise: (a) at least about 15%, by weight of the composition, of water; (b) from about 40% to about 84%, by weight of the composition, of soap; (c) from about 1% to about 30%, by weight of the composition, of carbohydrate structurant; and (d) from about 0.001% to about 10%, by weight of the composition, of cationic polymer. The bar compositions are preferably manufactured by a milling process.

  高含水量的清洁用香皂成分包括：(a) 组成重量的至少约15%的水；(b) 组成重量的约40%至约84%的肥皂；(c) 组成重量的约1%至约30%的碳水化合物结构体；以及(d) 组成重量的约0.001%至约10%的阳离子聚合物。这些香皂组成物最好通过磨粉过程制造。
• Silver halide photographic light sensitive material and hydrazine compound employed in it
  申请人：KONICA CORPORATION

  公开号：EP1011015A1

  公开（公告）日：2000-06-21

  A silver halide photographic photosensitive material is disclosed. The silver halide photographic photosensitive material comprises a hydrazine compound at least one alkyl group which has no atom other than carbon and hydrogen atoms, has three or more branches, and does not bond to aromatic ring directly.

  本发明公开了一种银卤化物感光照相材料。该银卤化物感光照相材料包括至少一个脂肪基的肼化合物，该脂肪基除碳和氢原子外没有其他原子，具有三个或更多的支链，并且不直接与芳香环键合。
• Agents and method for the protection of coatings and wood and other non-living organic substrates from deterioration by micro-organisms
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0038109A2

  公开（公告）日：1981-10-21

  The agents protect coatings and wood and other non-living organic materials, in particular textiles, from deterioration by microorganisms. The agents contain at least one compound of the formula wherein X is nitrogen or a CH group and R1 is a radikal of the formula wherein Ar, R and Z are as defined in claim one, or an acid addition salt thereof. The metod provided comprises applying at least one compound as just specified to, or incorporating it in, the material to be protected, in an antimicrobially effective amount.

  这些制剂可保护涂料、木材和其他非生物有机材料，特别是纺织品，免受微生物的侵蚀。药剂中至少含有一种式如下的化合物 其中 X 是氮或 CH 基团，R1 是式中的 Radikal。 其中 Ar、R 和 Z 如权利要求 1 所定义，或其酸加成盐。 本发明提供的方法包括将至少一种上述化合物以有效的抗菌量施用到待保护材料上，或将其加入待保护材料中。