2-Phenyl-4-allylthio-pyrimidin | 6203-95-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-Phenyl-4-allylthio-pyrimidin
• 英文别名: 4-allylsulfanyl-2-phenyl-pyrimidine；4-(Allylthio)-2-phenylpyrimidine；2-phenyl-4-prop-2-enylsulfanylpyrimidine
• CAS: 6203-95-8
• 化学式: C₁₃H₁₂N₂S
• 分子量: 228.318
• InChiKey: PWWLXLYEUHJYMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  51.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Heterocyclic sodium/proton exchange inhibitors and method
  申请人：Ahmad Saleem

  公开号：US20050137216A1

  公开（公告）日：2005-06-23

  Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or C—R 5 wherein R 5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; Z is a heteroaryl gorup, R 1 , R 2 , R 3 and R 4 are as defined herein, and where X is N, R 1 is preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above heterocyclic derivatives.

  所提供的杂环化合物是钠/质子交换（NHE）抑制剂，其结构如下 其中 n 为 1 至 5；X 为 N 或 C-R 5 其中 R 5 是 H、卤素、烯基、炔基、烷氧基、烷基、芳基或杂芳基；Z 是杂芳基高尔基，R 1 , R 2 , R 3 和 R 4 如本文所定义，其中 X 为 N，R 1 最好是芳基或杂芳基，可用作抗心绞痛和心脏保护剂。此外，还提供了一种利用上述杂环衍生物预防或治疗心绞痛、心脏功能障碍、心肌坏死和心律失常的方法。
• HETEROCYCLIC SODIUM/PROTON EXCHANGE INHIBITORS AND METHOD
  申请人：Bristol-Myers Squibb Company

  公开号：EP1224183B1

  公开（公告）日：2005-12-28
• US6887870B1
  申请人：——

  公开号：US6887870B1

  公开（公告）日：2005-05-03
• US7326705B2
  申请人：——

  公开号：US7326705B2

  公开（公告）日：2008-02-05
• [EN] HETEROCYCLIC SODIUM/PROTON EXCHANGE INHIBITORS AND METHOD<br/>[FR] INHIBITEURS HETEROCYCLIQUES D'ECHANGE SODIUM / PROTONS ET PROCEDES A CET EFFET
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2001027107A2

  公开（公告）日：2001-04-19

  Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure (I) wherein n is 1 to 5; X is N or C-R5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; Z is a heteroaryl group, R?1, R2, R3 and R4¿ are as defined herein, and where X is N, R1 is preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above heterocyclic derivatives.