N-(2,6-difluorobenzoyl)-N'-(4-benzyloxyphenyl)urea | 70312-33-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2,6-difluorobenzoyl)-N'-(4-benzyloxyphenyl)urea
• 英文别名: Benzamide, 2,6-difluoro-N-(((4-(phenylmethoxy)phenyl)amino)carbonyl)-；2,6-difluoro-N-[(4-phenylmethoxyphenyl)carbamoyl]benzamide
• CAS: 70312-33-3
• 化学式: C₂₁H₁₆F₂N₂O₃
• 分子量: 382.366
• InChiKey: IYEKVWVDGMIYIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Benzoylurea compounds and pesticidal compositions comprisingsame
  申请人：DUPHAR INTERNATIONAL RESEARCH B.V

  公开号：EP0116729A2

  公开（公告）日：1984-08-29

  The invention relates to new benzoylurea compounds of the general formula wherein R1 is a halogen atom, R2 is a hydrogen atom or a halogen atom, R3 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of chlorine, methyl and trifluormethyl, R4 is a hydrogen atom or represents 1-3 substituents which are selected from the group consisting of halogen, and alkyl, alkoxy, haloalkyl and haloalkoxy, having 1-4 carbon atoms, X is N or CH, n is 0 or 1, and R5 is a hydrogen atom, an alkyl group having 1-6 carbon atoms, an alkenyl group having 2-6 carbon atoms, or a cycloalkyl group having 3-6 carbon atoms, with the proviso, that, if n is 0 and Rs is a hydrogen atom, R3 is a hydrogen atom. The compounds have an -insecticidal and acaricidal activity. After having been processed to compositions, the compounds may be used for the control of insects and/or mites in a dosage of 1 to 5000 grams of active substance per hectare. In addition the compounds have an antitumor activity and may be used in pharmaceutical compositions.

  本发明涉及通式如下的新苯甲酰脲化合物 式中 R1 是卤素原子 R2 是氢原子或卤素原子 R3是氢原子或代表1或2个取代基，这些取代基选自氯、甲基和三氟甲基组成的组、 R4 是氢原子，或代表 1-3 个取代基，这些取代基可从具有 1-4 个碳原子的卤素、烷基、烷氧基、卤代烷基和卤代烷氧基组成的组中选出、 X 是 N 或 CH、 n 是 0 或 1，以及 R5 是氢原子、具有 1-6 个碳原子的烷基、具有 2-6 个碳原子的烯基或具有 3-6 个碳原子的环烷基，但如果 n 为 0 且 Rs 为氢原子，则 R3 为氢原子。 这些化合物具有杀虫和杀螨活性。在加工成组合物后，化合物可用于防治昆虫和/或螨虫，每公顷用量为 1 至 5000 克活性物质。此外，该化合物还具有抗肿瘤活性，可用于药物组合物中。
• Benzoylurea compounds, and pesticidal compositions comprising same
  申请人：DUPHAR INTERNATIONAL RESEARCH B.V

  公开号：EP0117320A1

  公开（公告）日：1984-09-05

  The invention relates to new benzoylurea compounds of the general formula wherein R, is a halogen atom, R2 is a hydrogen atom or a halogen atom, R3 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of chlorine, methyl and trifluoromethyl, R4 is a hydrogen atom, an alkyl group having 1-6 carbon atoms or a cycloalkyl group having 3-6 carbon atoms, R5 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, and A ist a phenyl group or a heteroaryl group having 1 or 2 nitrogen atoms, which groups may be substituted with 1-3 substituents which are selected from the group consisting of halogen, and alkyl, alkoxy, haloalkyl and haloalkoxy having 1-4 carbon atoms. The compounds have an insecticidal and acaricidal activity. After having been processed to compositions, the compounds may be used for control of insects and/or mites in a dosage from 1 to 5000 g of active substance per hectare. In addition the compounds have an anti-tumor activity and may be used in pharmaceutical compositions.

  本发明涉及通式如下的新苯甲酰脲化合物 式中 R，是卤素原子 R2 是氢原子或卤素原子、 R3 是氢原子或代表 1 个或 2 个从氯、甲基和三氟甲基组成的组中选出的取代基、 R4 是氢原子、具有 1-6 个碳原子的烷基或具有 3-6 个碳原子的环烷基、 R5 是氢原子或具有 1-4 个碳原子的烷基，以及 A 是苯基或具有 1 或 2 个氮原子的杂芳基，这些基团可被 1-3 个取代基取代，取代基可选 自卤素、烷基、烷氧基、卤代烷基和具有 1-4 个碳原子的卤代烷氧基组成的组。 这些化合物具有杀虫和杀螨活性。在加工成组合物后，化合物可用于防治昆虫和/或螨虫，每公顷用量为 1 至 5000 克活性物质。此外，这些化合物还具有抗肿瘤活性，可用于药物组合物中。
• Benzoyl-ureas having acaricide and insecticide activity
  申请人：ISTITUTO GUIDO DONEGANI S.p.A.

  公开号：EP0211665B1

  公开（公告）日：1991-06-12
• Composition active against mites, whitefly and thrips, pharmaceutical composition, and new benzoylureau compounds
  申请人：DUPHAR INTERNATIONAL RESEARCH B.V

  公开号：EP0116728B1

  公开（公告）日：1987-08-12
• US4350706A
  申请人：——

  公开号：US4350706A

  公开（公告）日：1982-09-21