3-Thiazolidinecarboxylic acid, 4-oxo-2-thioxo-, ethyl ester | 67952-24-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-Thiazolidinecarboxylic acid, 4-oxo-2-thioxo-, ethyl ester
• 英文别名: ethyl 4-oxo-2-sulfanylidene-1,3-thiazolidine-3-carboxylate
• CAS: 67952-24-3
• 化学式: C₆H₇NO₃S₂
• 分子量: 205.3
• InChiKey: HRXZNUFSACENKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  104
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Novel fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for caspases and other enzymes and the use thereof
  申请人：Cytovia, Inc.

  公开号：US20020150885A1

  公开（公告）日：2002-10-17

  The present invention relates to novel fluorescent dyes, novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of caspases and other enzymes involved in apoptosis in whole cells, cell lines and tissue samples derived from any living organism or organ. The reporter molecules and assay processes can be used in drug screening procedures to identify compounds which act as inhibitors or inducers of the caspase cascade in whole cells or tissues. The reagents and assays described herein are also useful for determining the chemosensitivity of human cancer cells to treatment with chemotherapeutic drugs. The present invention also relates to novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of type 2 methionine aminopeptidase, dipeptidyl peptidase IV, calpain, aminopeptidase, HIV protease, adenovirus protease, HSV-1 protease, HCMV protease and HCV protease.

  本发明涉及新型荧光染料、新型荧光报告分子和新的酶测定方法，可以用于检测整个细胞、细胞系和来自任何生物体或器官的组织样本中参与凋亡的caspase和其他酶的活性。报告分子和测定方法可用于药物筛选程序，以识别在整个细胞或组织中作为caspase级联抑制剂或诱导剂的化合物。本文介绍的试剂和测定也可用于确定人类癌细胞对化疗药物治疗的化学敏感性。本发明还涉及新型荧光报告分子和新的酶测定方法，可用于检测第2型甲硫氨酸肽酶、二肽基肽酶IV、钙蛋白酶、氨肽酶、HIV蛋白酶、腺病毒蛋白酶、HSV-1蛋白酶、HCMV蛋白酶和HCV蛋白酶的活性。
• EP1026988A4
  申请人：——

  公开号：EP1026988A4

  公开（公告）日：2005-03-30
• NOVEL FLUORESCENT REPORTER MOLECULES AND THEIR APPLICATIONS INCLUDING ASSAYS FOR CASPASES
  申请人：Cytovia, Inc.

  公开号：EP1026988A1

  公开（公告）日：2000-08-16
• EP1618205A2
  申请人：——

  公开号：EP1618205A2

  公开（公告）日：2006-01-25
• EP1618205A4
  申请人：——

  公开号：EP1618205A4

  公开（公告）日：2009-04-08