7-(2 (2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-desacetoxyceph-3-em-4-carboxylic acid pivaloyloxymethyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 7-(2 (2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-desacetoxyceph-3-em-4-carboxylic acid pivaloyloxymethyl ester
• 英文别名: 2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• 化学式: C₂₀H₂₅N₅O₇S₂
• 分子量: 511.6
• InChiKey: DASYMCLQENWCJG-MLGOLLRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  216
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• Operating method for an aerosol delivery device and aerosol delivery device
  申请人：PARI Pharma GmbH

  公开号：EP2380618A1

  公开（公告）日：2011-10-26

  The invention relates to a method for operating an aerosol delivery device (10), comprising the steps of generating a predetermined amount of an aerosol in the device (10) and inducing a transport flow in the device (10) for transporting at least a portion of the predetermined amount of the aerosol outside the device (10). During the aerosol generating step, the transport flow is first induced, then stopped after a predetermined first period of time and then induced again after a predetermined second period of time. Further, the invention relates to an aerosol delivery device (10) comprising an aerosol generator (3) for generating an aerosol in the device (10), a gas conveying element (1) for inducing a transport flow in the device (10) for transporting at least a portion of the generated aerosol outside the device (10), and a control configured, during the aerosol generating step, to first activate the gas conveying element (1), then deactivate the gas conveying element (1) after a predetermined first period of time and then activate the gas conveying element (1) again after a predetermined second period of time, so that the transport flow is first induced, then stopped after the first period of time and then induced again after the second period of time.

  本发明涉及一种气溶胶输送装置（10）的操作方法，包括以下步骤：在装置（10）内产生预定量的气溶胶，并在装置（10）内诱导输送流，以便将至少一部分预定量的气溶胶输送到装置（10）外。在气溶胶生成步骤中，首先诱导输送流，然后在预定的第一时间段后停止，然后在预定的第二时间段后再次诱导输送流。此外，本发明还涉及一种气溶胶输送装置 (10)，该装置包括一个气溶胶发生器 (3)，用于在装置 (10) 中产生气溶胶；一个气体输送元件 (1)，用于在装置 (10) 中诱导输送流，以便将所产生的气溶胶的至少一部分输送到装置 (10) 外；以及一个控制装置，该控制装置在气溶胶产生步骤中配置为首先激活气体输送元件 (1)，然后在预定的第一时间段后停用气体输送元件 (1)，然后在预定的第二时间段后再次激活气体输送元件 (1)，从而首先诱导输送流，然后在第一时间段后停止，然后在第二时间段后再次诱导输送流。
• POLYMER MOLDING COMPOUNDS CONTAINING PARTIALLY NEUTRALIZED AGENTS
  申请人：Dujardin Ralf

  公开号：US20100094230A1

  公开（公告）日：2010-04-15

  The invention relates to polymer molding compositions rendered antibacterial, antiprotozoic, or antimycotic by using partially neutralized active ingredients, to processes for their production, and to their use in moldings, in particular in medical items.
• Antibiotice Susceptibility Profiling Methods
  申请人：Shi Song

  公开号：US20110269130A1

  公开（公告）日：2011-11-03

  The invention provides methods for the rapid determination of the antibiotic susceptibility of a microorganism, such as, an infectious microorganism in a biological sample, using fluorescence in situ hybridization (“FISH”). Methods of the invention may be applied to the rapid identification, typing, antibiotic susceptibility determination, and/or antibiotic minimum inhibitory concentration (MIC) determination for any infectious microorganism, such as a Gram positive bacteria, a Gram negative bacteria, or a yeast.
• AEROSOL THERAPY DEVICE
  申请人：Gallem Thomas

  公开号：US20120037154A1

  公开（公告）日：2012-02-16

  The invention relates to an aerosol therapy device comprising: a housing; an aerosol generator, which is arranged in the housing; an air inlet ( 52 ), which is formed in the housing upstream of the aerosol generator ( 30 ); and an air outlet ( 51 ), which is formed in the housing downstream of the aerosol generator ( 30 ) to administer the aerosol produced, wherein an air flow from the air inlet ( 52 ) to the air outlet ( 51 ) can be generated by a negative pressure at the air outlet ( 51 ), wherein said air flow flows around the aerosol generator ( 30 ), characterized in that a truncated-cone-shaped flow channel ( 41 ), the central axis ( 44 ) of which extends in a curved manner, is arranged between the aerosol generator and the air outlet ( 51 ).
• OPERATING METHOD FOR AN AEROSOL DELIVERY DEVICE AND AEROSOL DELIVERY DEVICE
  申请人：Krüner Axel

  公开号：US20130112197A1

  公开（公告）日：2013-05-09

  The invention relates to a method for operating an aerosol delivery device ( 10 ), comprising the steps of generating a predetermined amount of an aerosol in the device ( 10 ) and inducing a transport flow in the device ( 10 ) for transporting at least a portion of the predetermined amount of the aerosol outside the device ( 10 ). During the aerosol generating step, the transport flow is first induced, then stopped after a predetermined first period of time and then induced again after a predetermined second period of time. Further, the invention relates to an aerosol delivery device ( 10 ) comprising an aerosol generator ( 3 ) for generating an aerosol in the device ( 10 ), a gas conveying element ( 1 } for inducing a transport flow in the device ( 10 ) for transporting at least a portion of the generated aerosol outside the device ( 10 ), and a control configured, during the aerosol generating step, to first activate the gas conveying element ( 1 ), then deactivate the gas conveying element ( 1 ) after a predetermined first period of time and then activate the gas conveying element ( 1 ) again after a predetermined second period of time, so that the transport flow is first induced, then stopped after the first period of time and then induced again after the second period of time.