1-cyclohexyloxycarbonyloxyethyl (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydron;dichloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 1-cyclohexyloxycarbonyloxyethyl (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydron;dichloride
• 化学式: C27H39Cl2N9O7S3
• 分子量: 768.8
• InChiKey: FFSANQNELHESQJ-LWBICVDYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.48
• 重原子数：
  48
• 可旋转键数：
  16
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  276
• 氢给体数：
  4
• 氢受体数：
  16

文献信息

• Cephalosporin ester derivatives, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0128029A2

  公开（公告）日：1984-12-12

  A compound of the formula: wherein R. is a hydrogen atom or a lower alkyl group; R2 is an unsubstituted or lower alkyl-substituted alicyclic alkyl group of 3 to 12 carbon atoms or a C3-6 alicyclic alkyl-substituted lower alkyl group or a pharmaceutically acceptable salt thereof, processes for preparing the same, a pharmaceutical composition thereof are provided. The compound has an improved absorbability and can be orally applied as antibiotics.

  式中的化合物： 其中 R.是氢原子或低级烷基；R2 是 3 至 12 个碳原子的未取代或低级烷基取代的脂环烷基或 C3-6 脂环烷基取代的低级烷基或其药学上可接受的盐、制备方法及其药物组合物。该化合物具有更好的可吸收性，可作为抗生素口服。
• COMPOSITIONS AND ASSAYS
  申请人：GENADAM THERAPEUTICS, INC.

  公开号：US20190234933A1

  公开（公告）日：2019-08-01

  The present disclosure contemplates methods for identifying candidate compounds or gene products useful in treating or ameliorating bacterial, fungal or viral infections; or for treating or ameliorating cancers or tumors characterized by interruption of pyroptosis. Compositions, methods of making, as well as kits, which utilize such pharmaceutical composition are also contemplated.
• US5120841A
  申请人：——

  公开号：US5120841A

  公开（公告）日：1992-06-09