5-Phenyl-3,6-dihydro-1,3,4-dihydrooxazin-2-on | 62501-39-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Phenyl-3,6-dihydro-1,3,4-dihydrooxazin-2-on
• 英文别名: 5-Phenyl-3,6-dihydro-1,3,4-oxadiazin-2-on；3,6-dihydro-5-phenyl-2H-1,3,4-oxadiazin-2-one；5-phenyl-3,6-dihydro-1,3,4-oxadiazin-2-one；2H-1,3,4-Oxadiazin-2-one, 3,6-dihydro-5-phenyl-
• CAS: 62501-39-7
• 化学式: C₉H₈N₂O₂
• mdl: MFCD01938298
• 分子量: 176.175
• InChiKey: RUWHMZIBEYGMPG-UHFFFAOYSA-N

物化性质

• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  ethyl N-[(Z)-(2-hydroxy-1-phenylethylidene)amino]carbamate 生成 5-Phenyl-3,6-dihydro-1,3,4-dihydrooxazin-2-on
  参考文献：
  名称：

  KATAUEH, ISAO;FUKASAVA, NOBUYUKI;NISINA, TANASI;KAMITANI, DZIODZI;TANAKA,+

  摘要：

  DOI：

文献信息

• Pharmaceutically active phenyl-thia-, oxa- or triazinones
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0080296A1

  公开（公告）日：1983-06-01

  Heterocyclic compounds of the formula wherein either X is -CR1R2and Y is -O-, -S- or-NR3-, wherein R1, R2 and R3, which may be the same of different, each is hydrogen or alkyl of up to 4 carbon atoms; or X is-O-, -S- or -NH- and Y is -CF1R2- wherein R1 and R2 have the meanings stated above; wherein either R4 is hydrogen, fluoro or chloro, or alkyl, alkenyl, halogenoalkyl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or alkoxy each of up to 6 carbon atom, and R5, R6 and R7, which may be the same or different, each is hydrogen, fluoro, chloro, bromo or iodo, or alkyl, alkenyl, halogenoalkyl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or alkoxy each of up to 6 carbon atoms, provided that R4, R5, R6 and R7 are not all hydrogen; or R4 is bromo and R5, R6 and R7 have the meanings stated above, provided that R5, R6and R7 are not all hydrogen; or R4 and R5 together, or R5 and R6 together, or R4 and R7 together, from the-CH=CH-CH=CH-group and the othertwo of R4, R5, R6 and R7 have the meanings stated above; processes for their manufacture and pharmaceutical compositions containing them. The compounds possess cardiotonic and/or antihypertensive activity.

  式中的杂环化合物 其中X为-CR1R2，Y为-O-、-S-或-NR3-，其中R1、R2和R3可以相同或不同，各自为氢或最多4个碳原子的烷基； 或 X 为-O-、-S-或-NH-，Y 为-CF1R2-，其中 R1 和 R2 具有上述含义； 其中，R4 是氢、氟或氯，或烷基、烯基、卤代烷基、氨基烷基、羟基烷基、烷氧基烷基或烷氧基，每个烷基最多 6 个碳原子；R5、R6 和 R7（可以相同或不同）各自是氢、氟、氯、溴或碘，或烷基、烯基、卤代烷基、氨基烷基、羟基烷基、烷氧基烷基或烷氧基，每个烷基最多 6 个碳原子，条件是 R4、R5、R6 和 R7 不全是氢； 或 R4 为溴，R5、R6 和 R7 具有上述含义，但 R5、R6 和 R7 并非都是氢； 或 R4 和 R5 一起，或 R5 和 R6 一起，或 R4 和 R7 一起，来自-CH=CH-CH=CH-基团，且 R4、R5、R6 和 R7 中的另外两个具有上述含义；它们的制造工艺和含有它们的药物组合物。这些化合物具有强心和/或抗高血压活性。
• Thiadiazine derivatives, and pharmaceutical compositions containing them
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0085227A1

  公开（公告）日：1983-08-10

  Heterocyclic compounds of the formula:- wherein A is a direct link, or is alkylene of 1 to 4 carbon atoms or alkenylene of 2 to 4 carbon atoms; wherein either X is -CR1R2- and Y is -0-, -S- or -NR3-, wherein R1, R2 and R3, which may be the same or different, each is hydrogen or alkyl of up to 4 carbon atoms; or X is-O-,-S- or-NH- and Y is-CR1R2- wherein R1 and R2 have the meanings stated above; and wherein Het is a 5- or 6- membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from nitrogen, oxygen or sulphur atoms, which ring may be unsubstituted or may bear one or two substituents as set out in claim 1, provided that when X is -CR1R2- and A is a direct link, Het is not unsubstituted 2-furyl; and salts thereof where appropriate; processes for their manufacture and pharmaceutical compositions containing them. The compounds possess cardiotonic and/or antihypertensive activity.

  分子式为：- 的杂环化合物 其中 A 为直接连接，或为 1 至 4 个碳原子的亚烷基或 2 至 4 个碳原子的烯基； 其中 X 为-CR1R2-，Y 为-0-、-S- 或-NR3-，其中 R1、R2 和 R3 可以相同或不同，各自为氢或最多 4 个碳原子的烷基； 或 X 是-O-、-S- 或-NH-，Y 是-CR1R2-，其中 R1 和 R2 具有上述含义； 其中Het是含有1、2或3个选自氮、氧或硫原子的杂原子的5-或6-成员杂环，该环可以是未取代的，也可以带有权利要求1所述的一个或两个取代基，条件是当X是-CR1R2-和A是直接连接时，Het不是未取代的2-呋喃基；及其适当的盐类；它们的制造工艺和含有它们的药物组合物。这些化合物具有强心和/或抗高血压活性。
• Thiadiazine, oxadiazine and triazine derivatives and pharmaceutical compositions containing them
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0086301A1

  公开（公告）日：1983-08-24

  Heterocyclic compounds of the formula: wherein either X is -CR1R2- and Y is -0-, -S- or -NHR3-, wherein R1, R2 and R3, which may be the same or different, each is hydrogen or alkyl of up to 4 carbon atoms; or X is -0-, -S- or -NH- and Y is -CR1R2- wherein R1 and R2 have the meanings stated above; wherein R4 and R5, which may be the same or different, each is hydrogen (but provided that R4 and R5 are not both hydrogen), or each is a group defined in claim 1 which is readily convertible into a carboxy group; processes for their manufacture; and pharmaceutical compositions containing them. The compounds possess cardiotonic and/or antihypertensive activity.

  式中X为-CR1R2-，Y为-0-、-S-或-NHR3-，其中R1、R2和R3可以相同或不同，各自为氢或最多4个碳原子的烷基；或X为-0-、-S-或-NH-，Y为-CR1R2-，其中R1和R2具有上述含义；其中R4和R5可以相同或不同，各自为氢(但条件是R4和R5不都是氢)，或各自为权利要求1中定义的基团，该基团易于转化为羧基；其制造工艺；以及含有它们的药物组合物。 这些化合物具有强心和/或抗高血压活性。
• Foamable polycarbonate compositions, articles and methods
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0158266A2

  公开（公告）日：1985-10-16

  A foamable thermoplastic composition comprising in admixture (a) a polycarbonate resin, alone, or with (b) a polyester, (c) a minor amount of a foaming agent and (d) a minor amount of an inorganic non-fibrous particulate nucleating agent, alone, or with a particulate organic polymeric material, wherein (d) has an aspect ratio of about 1 and a small particle size.

  一种可发泡热塑性塑料组合物，其混合物包括：(a) 聚碳酸酯树脂，单独使用或与 (b) 聚酯一起使用；(c) 少量发泡剂；(d) 少量无机非纤维微粒成核剂，单独使用或与微粒有机聚合物材料一起使用，其中(d) 的长径比约为 1，且粒径较小。
• Foamable polyetherimide resin formulation
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0181000A2

  公开（公告）日：1986-05-14

  The present invention relates to a foamable polyetherimide resin. These foamable polyetherimides have an effective amount of a chemical blowing agent which decomposes at a temperature equal to or greater than the glass transition temperature of the polyetherimide resin and does not have an adverse effect on the polyetherimide.

  本发明涉及一种可发泡聚醚酰亚胺树脂。这些可发泡聚醚酰亚胺含有有效量的化学发泡剂，其分解温度等于或高于聚醚酰亚胺树脂的玻璃转化温度，且不会对聚醚酰亚胺产生不利影响。