2-(diethylamino)ethyl 4-amino-2-hydroxybenzoate;hydron;chloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(diethylamino)ethyl 4-amino-2-hydroxybenzoate;hydron;chloride
• 化学式: C13H21ClN2O3
• 分子量: 288.77
• InChiKey: QVHDNNXTFDGCME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.89
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  75.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Therapeutic agent for glaucoma containing 2-phenyl-3-oxo-2H-1,4-benzothiazine derivatives
  申请人：SANTEN PHARMACEUTICAL CO., LTD

  公开号：EP0492164A1

  公开（公告）日：1992-07-01

  A therapeutic agent for glaucoma comprises 2-phenyl-3-oxo-2H-1,4-benthiazine derivatives especially (+)-(R)-3,4-Dihydro-2-[5-methoxy-2-[3-[N-methyl-N-[2-[(3,4-methylenedioxy) phenoxy]ethyl]amino]propoxy]phenyl]-4-methyl-3-oxo-2H-1,4-benzothiazine or its salt as active ingredient and pharmaceutically acceptable excipients. The therapeutic agent lowers the intraocular pressure upon topical or systemic administration.

  青光眼治疗剂包括 2-苯基-3-氧代-2H-1,4-苯并噻嗪衍生物，特别是 (+)-(R)-3,4- 二氢-2-[5-甲氧基-2-[3-[N-甲基-N-[2-[(3,4-亚甲基二氧)苯氧基]乙基]氨基]丙氧基]苯基]-4-甲基-3-氧代-2H-1,4-苯并噻嗪或其盐作为活性成分和药学上可接受的赋形剂。治疗剂在局部或全身给药后可降低眼内压。
• SUPPOSITORIES SUSTAINED IN THE LOWER RECTUM
  申请人：TAISHO PHARMACEUTICAL CO., LTD

  公开号：EP1319397A1

  公开（公告）日：2003-06-18

  A suppository of retaining in a lower region of rectum, which contains a suppository base containing: (A) a fatty acid triglyceride, (B) one or more C14-18 fatty acid glycerides, and (C) a base ingredient for retaining the suppository in the lower region of rectum, has quite high safety, does not melt by the body temperature when it is held by the fingers before insertion into the rectum so that it is easy to handle, does not deform by elevation of temperature during storage, and prevents stimulation to the rectum mucosa such as congestive hemorrhage and expansion of the rectum mucosa after the insertion.

  一种保留在直肠下部区域的栓剂，内含栓剂基质，其中含有： (A) 脂肪酸甘油三酯、 (B) 一种或多种 C14-18 脂肪酸甘油酯，以及 (C) 用于将栓剂保留在直肠下部的基本成分，具有相当高的安全性，在插入直肠前用手指握住时不会因体温而融化，因此易于操作，在储存期间不会因温度升高而变形，并可防止对直肠粘膜的刺激，如充血出血和插入后直肠粘膜膨胀。
• Preparation of submicron sized particles with polymorph control
  申请人：——

  公开号：US20030096013A1

  公开（公告）日：2003-05-22

  The present invention provides a method of preparing particles with polymorph and size control of a pharmaceutical compound, the method including the steps of: (1) providing a pharmaceutical compound in a first phase; (2) seeding the compound; (3) causing a phase change in the pharmaceutical compound to a second phase of a desired polymorphic form; and (4) wherein the mean particle size of the particles is less than 7 &mgr;m.

  本发明提供了一种制备具有多晶型和尺寸控制的药物化合物颗粒的方法，该方法包括以下步骤：(1)提供第一相中的药物化合物；(2)播种该化合物；(3)使药物化合物发生相变，变成所需多晶型的第二相；(4)其中颗粒的平均粒度小于7&mgr;m。
• Suppository of retaining in lower region of rectum
  申请人：——

  公开号：US20030185861A1

  公开（公告）日：2003-10-02

  A suppository of retaining in a lower region of rectum, which contains a suppository base containing: (A) a fatty acid triglyceride, (B) one or more C 14-18 fatty acid glycerides, and (C) a base ingredient for retaining the suppository in the lower region of rectum, has quite high safety, does not melt by the body temperature when it is held by the fingers before insertion into the rectum so that it is easy to handle, does not deform by elevation of temperature during storage, and prevents stimulation to the rectum mucosa such as congestive hemorrhage and expansion of the rectum mucosa after the insertion.

  一种保留在直肠下部区域的栓剂，它含有一种栓剂基质，其中含有 (A) 脂肪酸甘油三酯、 (B) 一种或多种 C 14-18 脂肪酸甘油酯，以及 (C) 用于将栓剂保留在直肠下部的基本成分，具有相当高的安全性，在插入直肠前用手指握住时不会因体温而融化，因此易于操作，在储存期间不会因温度升高而变形，并可防止对直肠粘膜的刺激，如充血出血和插入后直肠粘膜膨胀。
• PREPARATION OF SUBMICRON SIZED PARTICLES WITH POLYMORPH CONTROL AND NEW POLYMORPH OF ITRACONAZOLE
  申请人：BAXTER INTERNATIONAL INC.

  公开号：EP1534239A2

  公开（公告）日：2005-06-01