1-[2-(benzhydrylideneamino)oxyethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid;hydron;chloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[2-(benzhydrylideneamino)oxyethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid;hydron;chloride
• 化学式: C21H23ClN2O3
• 分子量: 386.9
• InChiKey: YZYRTEYMUTWJPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.59
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  62.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Compositions for affecting weight loss
  申请人：Orexigen Therapeutics, Inc.

  公开号：EP1870096A2

  公开（公告）日：2007-12-26

  Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is an opioid antagonist and the second compound causes increased agonism of a melanocortin 3 receptor (MC3-R) or a melanocortin 4 receptor (MC4-R) compared to normal physiological conditions Also disclosed are methods of affecting weight loss, increasing energy expenditure, increasing stiety in an individual, or suppresing the appetite of an individual, comprising identifying an individual in need thereof and treating that individual to antagonize opioid receptor activity and to enhance α-MSH activity

  公开了影响体重减轻的组合物，该组合物包含第一种化合物和第二种化合物，其中第一种化合物是阿片类拮抗剂，第二种化合物导致黑色素皮质素 3 受体(MC3-R)或黑色素皮质素 4 受体(MC4-R)的激动作用与正常生理条件相比增强；还公开了影响体重减轻的方法、增加能量消耗、增加个体体重或抑制个体食欲的方法，包括确定有需要的个体并对该个体进行治疗以拮抗阿片受体活性并增强α-MSH活性
• Compositions and methods for increasing insulin sensitivity
  申请人：Orexigen Therapeutics, Inc.

  公开号：EP2135603A2

  公开（公告）日：2009-12-23

  Methods and compositions for treating a blood glucose condition involve identifying a suitable subject and administering an effective amount of a composition that contains one or more of an opioid antagonist, an anticonvulsant, and a psychotherapeutic agent. The compositions can include insulin. In some embodiments, such methods and compositions can be used to modulate a blood glucose level. In preferred embodiments, such methods and compositions are useful for increasing a subject's sensitivity to insulin.

  治疗血糖状况的方法和组合物包括确定合适的受试者并施用有效量的组合物，该组合物含有阿片类拮抗剂、抗惊厥剂和精神治疗剂中的一种或多种。组合物可以包括胰岛素。在某些实施方案中，此类方法和组合物可用于调节血糖水平。在优选的实施方案中，这种方法和组合物有助于提高受试者对胰岛素的敏感性。
• Composition and methods for increasing insulin sensitivity
  申请人：Orexigen Therapeutics, Inc.

  公开号：EP2292220A2

  公开（公告）日：2011-03-09

  Methods and compositions for treating a blood glucose condition involve identifying a suitable subject and administering an effective amount of a composition that contains one or more of an opioid antagonist, anticonvulsant, and a psychotherapeutic agent. The compositions can include insulin. In some embodiments, such methods and compositions can be used to modulate a blood glucose level . In preferred embodiments, such methods and compositions are useful for increasing a subject's sensitivity to insulin.

  治疗血糖状况的方法和组合物包括确定合适的受试者并施用有效量的组合物，该组合物含有一种或多种阿片类拮抗剂、抗惊厥剂和精神治疗剂。组合物可以包括胰岛素。在某些实施方案中，此类方法和组合物可用于调节血糖水平。在优选的实施方案中，这种方法和组合物有助于提高受试者对胰岛素的敏感性。
• Compositions for affecting weight loss comprising naltrexone and bupropion
  申请人：Orexigen Therapeutics, Inc.

  公开号：EP2316456A1

  公开（公告）日：2011-05-04

  Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is an opioid antagonist and the second compound causes increased agonism of a melanocortin 3 receptor (MC3-R) or a melanocortin 4 receptor (MC4-R) compared to normal physiological conditions. Also disclosed are methods of affecting weight loss, increasing energy expenditure, increasing stiety in an individual, or suppresing the appetite of an individual, comprising identifying an individual in need thereof and treating that individual to antagonize opioid receptor activity and to enhance α-MSH activity.

  公开了用于影响减肥的组合物，该组合物包含第一种化合物和第二种化合物，其中第一种化合物是阿片类拮抗剂，第二种化合物导致黑色素皮质素3受体(MC3-R)或黑色素皮质素4受体(MC4-R)与正常生理条件相比激动作用增强。还公开了影响体重减轻、增加能量消耗、增加体重或抑制食欲的方法，包括确定有需要的个体并对其进行治疗，以拮抗阿片受体活性并增强α-MSH活性。
• COMPOSITION AND METHODS FOR INCREASING INSULIN SENSITIVITY
  申请人：Orexigen Therapeutics, Inc.

  公开号：EP3132792A1

  公开（公告）日：2017-02-22

  Methods and compositions for treating a blood glucose condition involve identifying a suitable subject and administering an effective amount of a composition that contains an opioid antagonist and a psychotherapeutic agent. The compositions can include insulin. In some embodiments, such methods and compositions can be used to modulate a blood glucose level. In preferred embodiments, such methods and compositions are useful for increasing a subject's sensitivity to insulin.

  治疗血糖状况的方法和组合物包括确定合适的受试者并施用有效量的组合物，该组合物含有阿片类拮抗剂和精神治疗剂。组合物可以包括胰岛素。在某些实施方案中，这种方法和组合物可用于调节血糖水平。在优选的实施方案中，这种方法和组合物有助于提高受试者对胰岛素的敏感性。