Pyridoxal diphosphate | 68385-44-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Pyridoxal diphosphate
• 英文别名: (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphono hydrogen phosphate
• CAS: 68385-44-4
• 化学式: C₈H₁₁NO₉P₂
• 分子量: 327.12
• InChiKey: BLPOUZDLIYAHLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  164
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• Phosphate mimics and methods of treatment using phosphatease inhibitors
  申请人：Sugen, Inc.

  公开号：US20040138255A1

  公开（公告）日：2004-07-15

  The invention relates to trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds and the physiologically acceptable salts and the prodrugs thereof. These compounds are expected to modulate the activity of protein tyrosine enzymes which are related to cellular signal transduction, in particular, protein tyrosine phosphatase, and therefore are expected to be useful in the prevention and treatment of disorders associated with abnormal protein tyrosine enzyme related cellular signal transduction such as cancer, diabetes, immuno-modulation, neurologic degenerative diseases, osteoporosis and infectious diseases. The invention also relates to the use of compounds containing fluoromethyl sulfonyl groups as phosphate mimics. These mimics may be used to inhibit, regulate or modulate the activity of a phosphate binding protein in a cell.

  本发明涉及三氟甲基磺酰和三氟甲基磺酰胺化合物及其生理上可接受的盐和前药。这些化合物预计能够调节与细胞信号转导相关的蛋白酪氨酸酶的活性，特别是蛋白酪氨酸磷酸酶，因此预计在预防和治疗与异常蛋白酪氨酸酶相关的细胞信号转导障碍，如癌症、糖尿病、免疫调节、神经退行性疾病、骨质疏松症和传染病方面有用。本发明还涉及含有氟甲基磺酰基团的化合物作为磷酸酯模拟物的用途。这些模拟物可用于抑制、调节或调节细胞中的磷酸结合蛋白的活性。
• Rapid action insulin formulations and pharmaceutical delivery systems
  申请人：Thermalin Inc.

  公开号：US10561711B2

  公开（公告）日：2020-02-18

  The present invention provides rapid-acting insulin and insulin analogue formulations. The invention further provides delivery devices, particularly infusion sets, which allow for the rapid absorption of insulin and insulin analogues, as well as other active agents. Methods of using the insulin and insulin analogue formulations as well as the insulin delivery devices for treating subjects with diabetes mellitus are also provided.

  本发明提供速效胰岛素和胰岛素类似物制剂。本发明还提供了可快速吸收胰岛素和胰岛素类似物以及其他活性剂的给药装置，特别是输液器。本发明还提供了使用胰岛素和胰岛素类似物制剂以及胰岛素给药装置治疗糖尿病患者的方法。
• Method for producing probiotically derived compounds
  申请人：Marshall J. Robert

  公开号：US20050118694A1

  公开（公告）日：2005-06-02

  A method for producing naturally derived beneficial compounds including dispersing a microbiological culture media including at least one live probiotic organism, and at least one nutraceutical and/or at least one nutritive agent in distilled water to form a broth, incubating the broth at a predetermined temperature for a select period of time to induce probiotic activity; halting the probiotic activity, and separating the desired compound from the broth.

  一种生产天然有益化合物的方法，包括在蒸馏水中分散微生物培养基（包括至少一种活的益生菌和至少一种保健品和/或至少一种营养剂）以形成肉汤，将肉汤在预定温度下培养一段时间以诱导益生菌活性；停止益生菌活性，并从肉汤中分离出所需的化合物。
• PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS
  申请人：Sugen, Inc.

  公开号：EP1212296A1

  公开（公告）日：2002-06-12
• METHOD FOR PRODUCING PROBIOTICALLY DERIVED COMPOUNDS
  申请人：Premier Research Labs, LP

  公开号：EP1836310A2

  公开（公告）日：2007-09-26