2-Ethyl-3-hydroxy-2,4,4-trimethyloxazolidine | 65162-38-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 2-Ethyl-3-hydroxy-2,4,4-trimethyloxazolidine
• 英文别名: 2-ethyl-3-hydroxy-2,4,4-trimethyl-1,3-oxazolidine
• CAS: 65162-38-1；67201-43-8
• 化学式: C₈H₁₇NO₂
• 分子量: 159.23
• InChiKey: WZZOSBRJFGEGCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Drug Resistance Reversal In Neoplastic Disease
  申请人：Patil Ghanshyam

  公开号：US20080200405A1

  公开（公告）日：2008-08-21

  The present invention is directed to compounds, compositions, and methods for halting or reversing the effects of chemoresistance in neoplastic diseases. In particular the use of hydroxylamines is described.

  本发明涉及用于阻止或逆转肿瘤性疾病化疗耐药效应的化合物、组合物和方法。具体描述了羟胺的使用。
• Use of at least one hydroxylamine compound for the treatment of eye disease
  申请人：Othera Holding, Inc.

  公开号：EP2052720A2

  公开（公告）日：2009-04-29

  Uses for the treatment or prevention of a number of ocular diseases or disorders are disclosed. In particular, uses are disclosed for the amelioration of diabetic retinophaty and other retinopathies, as well as uveitis, presbyopia, dry eye, glaucoma, blepharitis and rosacea of the eye. The uses comprise administration of a composition comprising an ophtalmalogically acceptable carrier or diluent and a hydroxylamine compound in a therapeutically sufficient amount to prevent, retard the development or reduce the symptoms of one or more of the ophthalmic conditions.

  已公开的用途包括治疗或预防多种眼部疾病或失调。 特别是公开了用于改善糖尿病视网膜病变和其他视网膜病变，以及葡萄膜炎、老花眼、干眼症、青光眼、眼睑炎和酒渣鼻的用途。 这些用途包括施用由眼科可接受的载体或稀释剂和羟胺化合物组成的组合物，其治疗量足以预防、延缓一种或多种眼科疾病的发展或减轻其症状。
• Method for treatment of radiologically-dense breasts
  申请人：Proctor Peter Herbert

  公开号：US10028943B2

  公开（公告）日：2018-07-24

  Nitrone, nitroso, and nitroxide spintraps and spin labels and their reduction products are claimed for the treatment of dense breasts.

  硝酮、亚硝基和亚硝基氧化物纺锤体和纺锤体标签及其还原产品声称可用于治疗致密乳房。
• Amelioration of macular degeneration and other ophthalmic diseases
  申请人：Matier L. William

  公开号：US20050130906A1

  公开（公告）日：2005-06-16

  Methods for the treatment or prevention of a number of ocular diseases or disorders are disclosed. In particular, methods are disclosed for the amelioration of macular degeneration, diabetic retinopathy and other retinopathies, as well as uveitis, presbyopia, dry eye, glaucoma, blepharitis and rosacea of the eye. The methods comprise administration of a compositions comprising an ophthalmologically acceptable carrier or diluent and a hydoxylamine compound in a therapeutically sufficient amount to prevent, retard the development or reduce the symptoms of one or more of the ophthalmic conditions.

  本文公开了治疗或预防多种眼部疾病或失调的方法。特别是公开了用于改善黄斑变性、糖尿病视网膜病变和其他视网膜病变，以及葡萄膜炎、老花眼、干眼症、青光眼、眼睑炎和酒渣鼻的方法。这些方法包括施用包含眼科可接受载体或稀释剂和水氧胺化合物的组合物，其治疗量足以预防、延缓发展或减轻一种或多种眼科疾病的症状。
• HYDROXYLAMINES AND DERIVATIVES AS ANTI-ANGIOGENIC AGENTS
  申请人：Othera Holding, Inc.

  公开号：EP1986648A2

  公开（公告）日：2008-11-05