A method for treating an addiction disorder (such as an addiction to or dependency on stimulants, nicotine, morphine, heroin, other opiates, amphetamines, cocaine, and/or alcohol) in a patient is disclosed. The method includes administering to the patient a first &agr;
3
&bgr;
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nicotinic receptor antagonist and administering to the patient a second &agr;
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&bgr;
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nicotinic receptor antagonist. The second &agr;
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&bgr;
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nicotinic receptor antagonist is different than the first &agr;
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&bgr;
4
nicotinic receptor antagonist, and the first &agr;
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&bgr;
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nicotinic receptor antagonist and the second &agr;
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&bgr;
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nicotinic receptor antagonist are administered simultaneously or non-simultaneously. Compositions which include a first &agr;
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&bgr;
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nicotinic receptor antagonist and a second &agr;
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&bgr;
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nicotinic receptor antagonist are also described. Examples of suitable &agr;
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&bgr;
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nicotinic receptor antagonists for use in the present invention's methods and compositions include mecamylamine,
18
-methoxycoronaridine, bupropion, dextromethorphan, dextrorphan, and phamaceutically acceptable salts and solvates thereof. A method of evaluating a compound for its effectiveness in treating addiction disorders is also described.
公开了一种治疗患者成瘾症(如对兴奋剂、
尼古丁、
吗啡、
海洛因、其他鸦片制剂、苯
丙胺、
可卡因和/或
酒精成瘾或依赖)的方法。该方法包括向患者施用第一&agr;
3
&bgr;
4
尼古丁受体拮抗剂,并向患者施用第二种 &agr;
3
&bgr;
4
烟碱受体拮抗剂。第二种&agr;
3
&bgr;
4
烟碱受体拮抗剂与第一种 &agr;
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&bgr;
4
尼古丁受体拮抗剂不同,而第一个&agr;
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&bgr;
4
尼古丁受体拮抗剂和第二&agr;
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&bgr;
4
烟碱受体拮抗剂同时或非同时给药。包括第一&agr;
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&bgr;
4
烟碱受体拮抗剂和第二种 &agr;
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&bgr;
4
烟碱受体拮抗剂。合适的 &agr;
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&bgr;
4
用于本发明的方法和组合物中的
烟碱受体拮抗剂包括麦卡明、
18
-甲氧
氯雷他定、
安非他酮、
右美沙芬、右旋沙芬以及它们的法玛可接受盐和溶液。还描述了一种评估化合物治疗成瘾症有效性的方法。