[(4-甲氧基-2-硝基苯基)甲基]三苯基鏻溴化物 | 886442-56-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: [(4-甲氧基-2-硝基苯基)甲基]三苯基鏻溴化物
• 英文名称: (4-methoxy-2-nitrobenzyl)triphenylphosphonium bromide
• 英文别名: 4-methoxy-2-nitrobenzyltriphenylphosphonium bromide；[(4-Methoxy-2-nitrophenyl)methyl]triphenylphosphonium Bromide；(4-methoxy-2-nitrophenyl)methyl-triphenylphosphanium;bromide
• CAS: 886442-56-4
• 化学式: Br*C₂₆H₂₃NO₃P
• 分子量: 508.351
• InChiKey: UOGAUEAECQVDOW-UHFFFAOYSA-M

物化性质

• 溶解度：
  甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [(4-甲氧基-2-硝基苯基)甲基]三苯基鏻溴化物 在 18-冠醚-6 potassium carbonate 作用下， 以 二氯甲烷 为溶剂， 生成 4-Methoxy-2-nitro-1-[(1Z,3E)-4-(2-nitro-phenyl)-buta-1,3-dienyl]-benzene
  参考文献：
  名称：

  Synthesis of arcyriaflavin B

  摘要：

  DOI：

  10.1016/s0040-4039(00)81677-9
• 作为产物：
  描述：

  4-甲基-3-硝基苯甲醚 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 作用下， 以 四氯化碳 、 二氯甲烷 为溶剂， 反应 32.0h， 生成 [(4-甲氧基-2-硝基苯基)甲基]三苯基鏻溴化物
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents

  摘要：

  A series of analogs with nitro or serinamide substituents at the C-2'-, C-5'-, or C-C-position of the combretastatin A-4 (CA4) B-ring was synthesized and evaluated for cytotoxic effects against heart endothelioma cells, blood flow reduction to tumors in SCID mice, and as inhibitors of tubulin polymerization. The synthesis of these analogs typically featured a Wittig reaction between a suitably functionalized arylaldehyde and an arylphosphonium salt followed by separation of the resultant F and Z-isomers. several of these nitrogen-modified CA4 derivatives (both amino and nitro) demonstrate significant inhibition of tubulin assembly as well as cytotoxicity and in vivo blood flow reduction. 2'-Aminostilbenoid 7 and 2'-amino-3'-hydroxystilbenoid 29 proved to be the most active in this series. Both compounds, 7 and 29, have the potential for further pro-drug modification and development as vascular disrupting agents for treatment of solid tumor cancers and certain ophthalmological diseases. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.12.033

文献信息

• Selenium-catalyzed reductive cyclization and carbocyclization of 2,2′-dinitrostilbenes with carbon monoxide: One-shot synthesis of indolo[1,2-c]quinazolinones
  作者：Rui Umeda、Shigeru Morishita、Yutaka Nishiyama

  DOI：10.1002/hc.20685

  日期：——

  When 2,2′-dinitrostilbene derivatives were allowed to react with carbon monoxide in the presence of a catalytic amount of selenium, reductive cyclization and carbocyclization proceeded to give indolo[1,2-c]quinazolin-6(5H)-ones, containing both indole and cyclic urea units, in moderate yields. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 22:571–575, 2011; View this article online at wileyonlinelibrary

  当 2,2'-二硝基二苯乙烯衍生物在催化量的硒存在下与一氧化碳反应时，还原性环化和碳环化进行得到吲哚[1,2-c]喹唑啉-6(5H)-酮，含有吲哚和环脲单元，产量适中。© 2011 Wiley Periodicals, Inc. 杂原子化学 22:571–575, 2011; 在 wileyonlinelibrary.com 上在线查看这篇文章。DOI 10.1002/hc.20685
• Towards solomonamide A: asymmetric synthesis of the unusual γ-amino acid part
  作者：Nerella Kavitha、Vemula Praveen Kumar、Srivari Chandrasekhar

  DOI：10.1016/j.tetlet.2013.02.032

  日期：2013.4

  Fully functional and differentially protected synthesis of the unusual gamma-amino acid part of the very powerful anti-inflammatory cyclic peptide solomonamide A has been achieved in a straight forward manner in good yields. (C) 2013 Elsevier Ltd. All rights reserved.
• Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4
  作者：John J. Hall、Madhavi Sriram、Tracy E. Strecker、Justin K. Tidmore、Christopher J. Jelinek、G.D. Kishore Kumar、Mallinath B. Hadimani、George R. Pettit、David J. Chaplin、Mary Lynn Trawick、Kevin G. Pinney

  DOI：10.1016/j.bmcl.2008.07.070

  日期：2008.9

  A new trifluorinated amino-combretastatin analogue, (Z)-2-(40-methoxy-3'-aminophenyl)-1-(3,4,5-trif uorophenyl) ethene, prepared by chemical synthesis, was found to be a potent inhibitor of tubulin assembly (IC50 = 2.9 mu M), and cytotoxic against selected human cancer cell lines. This new lead compound is among the most active from a group of related structural modifications. (C) 2008 Elsevier Ltd. All rights reserved.