[(4S,12Z)-18-羟基-4-甲基-2,8-二氧代-3-氧杂双环[12.4.0]十八碳-1(18),12,14,16-四烯-16-基]硫酸氢酯 | 132505-04-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 中文名称: [(4S,12Z)-18-羟基-4-甲基-2,8-二氧代-3-氧杂双环[12.4.0]十八碳-1(18),12,14,16-四烯-16-基]硫酸氢酯
• 英文名称: Zearelenone-4-sulfate
• 英文别名: [(4S,12E)-18-hydroxy-4-methyl-2,8-dioxo-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraen-16-yl] hydrogen sulfate
• CAS: 132505-04-5
• 化学式: C₁₈H₂₂O₈S
• 分子量: 398.4
• InChiKey: GQAJNGUAQKYPCH-QBODLPLBSA-N

物化性质

• 密度：
  1.328±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  136
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• BIOMARKER FOR DETECTING ZEARALENONE EFFECT
  申请人：Erber Aktiengesellschaft

  公开号：EP3663413A1

  公开（公告）日：2020-06-10

  The present invention relates to a novel method for detecting zearalenone (ZEN) effect comprising determining the expression level of at least one miRNA in a test sample, as well as to a novel use of at least one miRNA for detecting zearalenone (ZEN) effect in a test sample.

  本发明涉及一种检测玉米赤霉烯酮（ZEN）效应的新方法，该方法包括确定测试样本中至少一种 miRNA 的表达水平，以及至少一种 miRNA 在检测测试样本中玉米赤霉烯酮（ZEN）效应中的新用途。
• Polypeptide for hydrolytic cleavage of zearalenone and/or zearalenone derivatives, isolated polynucleotide thereof as well as a polypeptide containing an additive, use of same as well as a process
  申请人：Erber Aktiengesellschaft

  公开号：US10076125B2

  公开（公告）日：2018-09-18

  The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.

  本发明涉及一种用于水解裂解玉米赤霉烯酮和/或至少一种玉米赤霉烯酮衍生物的多肽，所述多肽是一种水解酶，其氨基酸序列选自 SEQ ID NO: 1-15 或其功能变体组成的组，其中功能变体的序列与至少一个氨基酸序列至少有 40%相同。本发明还涉及：含有该多肽的添加剂；编码该多肽的分离多核苷酸；以及使用该多肽水解裂解玉米赤霉烯酮和/或至少一种玉米赤霉烯酮衍生物的方法。
• POLYPEPTIDE FOR HYDROLYTIC CLEAVAGE OF ZEARALENONE AND/OR ZEARALENONE DERIVATIVES, ISOLATED POLYNUCLEOTIDE THEREOF AS WELL AS A POLYPEPTIDE CONTAINING AN ADDITIVE, USE OF SAME AS WELL AS A PROCESS
  申请人：ERBER AKTIENGESELLSCHAFT

  公开号：US20160345606A1

  公开（公告）日：2016-12-01

  The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
• MEANS AND METHODS FOR CLEAVAGE OF ZEARALENONE
  申请人：ERBER AKTIENGESELLSCHAFT

  公开号：US20210371835A1

  公开（公告）日：2021-12-02

  The present invention relates to a method for increasing the stability of an α/β-hydrolase. In addition, the present invention relates to an α/β-hydrolase obtainable by the method of the present invention. Also provided are α/β-hydrolases having a decreased grand average of hydropathy (GRAVY) value and/or comprising specific mutations. In addition, the present invention concerns a use of an α/β-hydrolase of the present invention for degrading zearalenone (ZEN).
• [EN] BIOMARKER<br/>[FR] BIOMARQUEUR
  申请人：ERBER AG

  公开号：WO2020115270A2

  公开（公告）日：2020-06-11

  The present invention relates to a novel method for detecting zearalenone (ZEN) effect comprising determining the expression level of at least one miRNA in a test sample, as well as to a novel use of at least one miRNA for detecting zearalenone (ZEN) effect in a test sample.