[(1S,3S,6R,8R)-8-hydroxy-3-methyl-5-oxo-2,9-dioxatricyclo[4.3.1.03,8]decan-10-yl]methyl benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(1S,3S,6R,8R)-8-hydroxy-3-methyl-5-oxo-2,9-dioxatricyclo[4.3.1.03,8]decan-10-yl]methyl benzoate
• 化学式: C₁₇H₁₈O₆
• 分子量: 318.32
• InChiKey: BANPEMKDTXIFRE-LKGUYIIYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• PHARMACEUTICAL COMPOSITION FOR TREATING AND PREVENTING DEGENERATIVE NEUROLOGICAL DISORDERS, CONTAINING, AS ACTIVE INGREDIENT, MIXTURE EXTRACT OF MOUTAN ROOT BARK, ANGELICA DAHURICA ROOT AND BUPLEURUM ROOT OR FRACTION THEREOF
  申请人：University-Industry Cooperation Group of Kyung Hee University

  公开号：EP3199171A1

  公开（公告）日：2017-08-02

  The present invention relates to a pharmaceutical composition for treating and preventing degenerative neurological disorders, containing, as an active ingredient, a mixture extract of two or more types selected from the group consisting of Moutan Root Bark, Angelica Dahurica Root, and Bupleurum Root, or a fraction thereof. Specifically, the extract of the mixture of the present invention exhibits a recovery effect on mitochondrial function damage, a relieving effect on endoplasmic reticulum stress and also exhibits simultaneously an inhibitory effect on inflammatory response, which are remarkably improved compared with those exhibited in an in vitro single extract, and the extract of the mixture significantly exhibits an improvement effect on motor coordination and a protective effect on dopaminergic neurons in a Parkinson's disease animal model, and thus the extract of the mixture of the present invention or a fraction thereof can be useful as an active ingredient of a pharmaceutical composition for treating and preventing degenerative neurological disorders.

  本发明涉及一种用于治疗和预防神经系统退行性疾病的药物组合物，其有效成分包含两种或两种以上的混合提取物，这些混合提取物选自木丹根树皮、白芷根和柴胡根或其馏分组成的组。具体来说，本发明的混合物提取物对线粒体功能损伤有恢复作用，对内质网应激有缓解作用，同时对炎症反应有抑制作用，这些作用与体外单一提取物相比有明显改善、因此，本发明的混合物提取物或其馏分可用作治疗和预防退行性神经系统疾病的药物组合物的活性成分。
• Pharmaceutical composition containing combination extracts of Moutan Root Bark, Angelica Dahurica Root, bupleurum root or fractions thereof for prevention and treatment of neurodegenerative disorder
  申请人：UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY

  公开号：US10660928B2

  公开（公告）日：2020-05-26

  The present invention relates to a pharmaceutical composition for treating and preventing degenerative neurological disorders, containing, as an active ingredient, a mixture extract of two or more types selected from the group consisting of Moutan Root Bark, Angelica Dahurica Root, and Bupleurum Root, or a fraction thereof. Specifically, the extract of the mixture of the present invention exhibits a recovery effect on mitochondrial function damage, a relieving effect on endoplasmic reticulum stress and also exhibits simultaneously an inhibitory effect on inflammatory response, which are remarkably improved compared with those exhibited in an in vitro single extract, and the extract of the mixture significantly exhibits an improvement effect on motor coordination and a protective effect on dopaminergic neurons in a Parkinson's disease animal model, and thus the extract of the mixture of the present invention or a fraction thereof can be useful as an active ingredient of a pharmaceutical composition for treating and preventing degenerative neurological disorders.

  本发明涉及一种用于治疗和预防神经系统退行性疾病的药物组合物，其有效成分包含两种或两种以上的混合提取物，这些混合提取物选自木丹根树皮、白芷根和柴胡根或其馏分组成的组。具体来说，本发明的混合物提取物对线粒体功能损伤有恢复作用，对内质网应激有缓解作用，同时对炎症反应有抑制作用，这些作用与体外单一提取物相比有明显改善、因此，本发明的混合物提取物或其馏分可用作治疗和预防退行性神经系统疾病的药物组合物的活性成分。
• Total glycosides of paeony, method to prepare the same and uses thereof
  申请人：——

  公开号：US20030232102A1

  公开（公告）日：2003-12-18

  This invention provides a composition comprising Paeoniflorin, Albiflorin, Oxypaeoniflorin, and Benzoylpaeomiflorin. This invention also provides a pharmaceutical composition comprising an effective amount of Paeoniflorin, Albiflorin, Wxypaeoniflorin, and Benzoylpaeomiflorin and a pharmaceutically acceptable carrier. Finally, this invention provides a method to make the above composition.

  本发明提供了一种包含芍药苷、白花蛇舌草苷、氧化芍药苷和苯甲酰芍药苷的组合物。本发明还提供了一种药物组合物，该组合物包含有效量的芍药苷、白花蛇舌草苷、氧基芍药苷和苯甲酰芍药苷以及药学上可接受的载体。最后，本发明提供了一种制造上述组合物的方法。
• PHARMACEUTICAL COMPOSITION CONTAINING COMBINATION EXTRACTS OF MOUTAN ROOT BARK, ANGELICA DAHURICA ROOT, BUPLEURUM ROOT OR FRACTIONS THEREOF FOR PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISORDER
  申请人：UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY

  公开号：US20170224754A1

  公开（公告）日：2017-08-10

  The present invention relates to a pharmaceutical composition for treating and preventing degenerative neurological disorders, containing, as an active ingredient, a mixture extract of two or more types selected from the group consisting of Moutan Root Bark, Angelica Dahurica Root, and Bupleurum Root, or a fraction thereof. Specifically, the extract of the mixture of the present invention exhibits a recovery effect on mitochondrial function damage, a relieving effect on endoplasmic reticulum stress and also exhibits simultaneously an inhibitory effect on inflammatory response, which are remarkably improved compared with those exhibited in an in vitro single extract, and the extract of the mixture significantly exhibits an improvement effect on motor coordination and a protective effect on dopaminergic neurons in a Parkinson's disease animal model, and thus the extract of the mixture of the present invention or a fraction thereof can be useful as an active ingredient of a pharmaceutical composition for treating and preventing degenerative neurological disorders.
• US6162459A
  申请人：——

  公开号：US6162459A

  公开（公告）日：2000-12-19