Acetamide, N-((methylamino)carbonyl)-N-phenyl- | 72570-69-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Acetamide, N-((methylamino)carbonyl)-N-phenyl-
• 英文别名: N-(methylcarbamoyl)-N-phenylacetamide
• CAS: 72570-69-5
• 化学式: C₁₀H₁₂N₂O₂
• 分子量: 192.21
• InChiKey: NECIDYRIOVUIQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] TYROSINE BIOCONJUGATION THROUGH AQUEOUS ENE-LIKE REACTIONS<br/>[FR] BIOCONJUGAISON DE LA TYROSINE PAR DES RÉACTIONS DE TYPE ÈNE EN MILIEU AQUEUX
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2011079315A1

  公开（公告）日：2011-06-30

  A new and versatile class of cyclic diazodicarboxamides that reacts efficiently and selectively with phenols and the phenolic side chain of tyrosine through an Ene-like reaction is reported. This mild aqueous tyrosine ligation reaction works over a broad pH range and expands the repertoire of aqueous chemistries available for small molecule, peptide, and protein modification. The tyrosine ligation reactions are shown to be compatible with the labeling of native enzymes and antibodies in buffered aqueous solution. This reaction provides a novel synthetic approach to bispecific antibodies. This reaction will find broad utility in peptide and protein chemistry and in the chemistry of phenol-containing compounds.