8-Phenyloctyl isothiocyanate | 157469-20-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 8-Phenyloctyl isothiocyanate
• 英文别名: 8-isothiocyanatooctylbenzene
• CAS: 157469-20-0
• 化学式: C₁₅H₂₁NS
• 分子量: 247.4
• InChiKey: ASHKCODNQLPFEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  44.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] N-ACYLETHANOLAMINE HYDROLYZING ACID AMIDASE (NAAA) INHIBITORS AND THEIR USE THEREOF<br/>[FR] INHIBITEURS D'AMIDASE ACIDE (NAAA) HYDROLYSANT LA N-ACYLÉTHANOLAMINE ET LEUR UTILISATION
  申请人：UNIV NORTHEASTERN

  公开号：WO2015179190A1

  公开（公告）日：2015-11-26

  A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. Compounds of Formula I are inhibitors of N-acylethanolamine hydrolyzing acid amidase (NAAA). The present technology is directed to compounds, compositions, and methods to inhibit N-acylethanolamine hydrolyzing acid amidase and to treat N-acylethanolamine hydrolyzing acid amidase mediated conditions in a subject.

  一种化合物被表示为化学式I，其互变异构体、立体异构体或其药学上可接受的盐。化学式I的化合物是N-酰乙醇胺水解酸酰胺酶（NAAA）的抑制剂。本技术涉及到抑制N-酰乙醇胺水解酸酰胺酶的化合物、组合物和方法，以及治疗受试者中的N-酰乙醇胺水解酸酰胺酶介导的疾病。
• N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof
  申请人：Northeastern University

  公开号：US10640494B2

  公开（公告）日：2020-05-05

  A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Compounds of Formula I are inhibitors of N-acylethanolamine hydrolyzing acid amidase (NAAA).

  一种化合物表示为式 I、其同分异构体、立体异构体或其药学上可接受的盐： 式 I 的化合物是 N-酰乙醇胺水解酸酰胺酶（NAAA）的抑制剂。
• N-ACYLETHANOLAMINE HYDROLYZING ACID AMIDASE (NAAA) INHIBITORS AND THEIR USE THEREOF
  申请人：Northeastern University

  公开号：EP3145505A1

  公开（公告）日：2017-03-29
• N-Acylethanolamine Hydrolyzing Acid Amidase (NAAA) Inhibitors And Their Use Thereof
  申请人：NORTHEASTERN UNIVERSITY

  公开号：US20170114050A1

  公开（公告）日：2017-04-27

  A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. Compounds of Formula I are inhibitors of N-acylethanolamine hydrolyzing acid amidase (NAAA). The present technology is directed to compounds, compositions, and methods to inhibit N-acylethanolamine hydrolyzing acid amidase and to treat N-acylethanolamine hydrolyzing acid amidase mediated conditions in a subject.
• US9963444B2
  申请人：——

  公开号：US9963444B2

  公开（公告）日：2018-05-08