2-chloro-2'-methyl-6'-methoxy-N-(isopropoxymethyl)-acetanilide | 78193-94-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-2'-methyl-6'-methoxy-N-(isopropoxymethyl)-acetanilide
• 英文别名: N-(isopropoxymethyl)-2'-methoxy-6'-methyl-2-chloroacetanilide；2'-methoxy-6'-methyl-N-(isopropoxymethyl)-2-chloroacetanilide；2'-Methyl, 6'-Methoxy-(N-Isopropoxymethyl) 2-Chloroacetanilide；α-chloro-N-(2-methoxy-6-methylphenyl)-N-(1-methylethoxymethyl) acetamide；Acetamide, 2-chloro-N-(2-methoxy-6-methylphenyl)-N-((1-methylethoxy)methyl)-；2-chloro-N-(2-methoxy-6-methylphenyl)-N-(propan-2-yloxymethyl)acetamide
• CAS: 78193-94-9
• 化学式: C₁₄H₂₀ClNO₃
• 分子量: 285.771
• InChiKey: YGTYRMDZBFYUCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-(chloromethyl)-2'-methoxy-6'-methyl-2-chloroacetanilide 以 异丙醇 为溶剂， 以100%的产率得到2-chloro-2'-methyl-6'-methoxy-N-(isopropoxymethyl)-acetanilide
  参考文献：
  名称：

  Process for the production of haloacylamides

  摘要：

  本文披露了一种新的过程，其特点是通过适当的卤代酰胺之一的取代基具有反应性卤素原子与适当的醇或硫醇反应制备苯甲酰胺类化合物，其中2',6'-二乙基-N-(甲氧甲基)2-氯乙酰苯胺（通用名阿拉克洛）为典型化合物。

  公开号：

  US05155272A1

文献信息

• Transetherification in amides
  申请人：Monsanto Company

  公开号：US04296254A1

  公开（公告）日：1981-10-20

  The disclosure herein pertains to the preparation of N-(alkoxymethyl)- and other N-methylene ether-substituted 2-haloacetamides from other N-methylene ether-substituted 2-haloacetamides and the appropriate alcohol by a transetherification process.

  本公开涉及通过转醚化过程，从其他N-亚甲基醚取代的2-卤代乙酰胺和适当的醇制备N-(烷氧甲基)-和其他N-亚甲基醚取代的2-卤代乙酰胺。
• A process for the in-solvent, in-situ generation of N-substituted-2-haloacetanilides
  申请人：MONSANTO COMPANY

  公开号：EP0037656A1

  公开（公告）日：1981-10-14

  The present invention is directed to a process for the preparation of certain N-substituted -2-haloacetanilides via the reaction of a secondary 2-haloacetanilide with a haloalkyl ether, particularly, halomethyl ethers, which comprises forming the ether in situ by the in-solvent reaction of an alcohol, formaldehyde or other aldehyde and an acid halide to produce high purity haloalkyl ethers, while decreasing the concentration of undesirable bis by products, as for example bis(chloromethyl) ether. The ether formed in situ thereafter reacts with the secondary 2-haloacetanilide in the presence of a phase transfer catalyst and base to form the N-substituted-2-haloacetanilide.

  本发明涉及一种通过仲2-卤乙酰苯胺与卤代烷基醚，特别是卤代甲基醚反应制备某些N-取代-2-卤乙酰苯胺的工艺，该工艺包括通过醇、甲醛或其他醛与酸卤化物的溶剂内反应原位形成醚，以生成高纯度的卤代烷基醚，同时降低不良双副产物，如双（氯甲基）醚的浓度。随后，原位形成的醚在相转移催化剂和碱的作用下与仲基 2-卤代乙酰苯胺反应，形成 N-取代的 2-卤代乙酰苯胺。
• Use of 2,4-disubstituted-5-thiazolecarboxylic acids and derivatives for reducing injury to crop plants by acetamide herbicides
  申请人：MONSANTO COMPANY

  公开号：EP0064353A1

  公开（公告）日：1982-11-10

  2,4-Disubstituted-5-thiazolecarboxylic acids and derivatives thereof have been found to reduce herbicidal injury of corn, rice and sorghum plants due to the application thereto of an acetamide herbicide selected from the ethyl ester of N-chloroacetyl-N-(2,6-diethylphenyl) glycine; 2-chloro-2',3'-dimethyl-N-(isopropyl)acetanilide; 2-chloro-2',6'-dimethyl-N-(1-pyrazolymethyl)acetanilide; 2-chloro-6'-trifluoromethyl-N-(isopropoxymethyl)acetanilide; 2-chloro-2'-methyl-6'-trifluoromethyl-N-(isopropoxymethyl)-acetanilide; 2-chloro-2'-methyl-6'-methoxy-N-(isopropoxymethyl)acetanilide; 2-chloro-2'-methyl-6'-methoxy-N-(propoxymethyl)acetanilide; 2-chloro-2'-methyl-6'-ethoxy-N-(propoxymethyl)acetanilide; 2-chloro-2'-isobutoxy-6'-methyl-N-(propoxymethyl)acetanilide; 2-chloro-2'-isobutoxy-6'-ethyl-N-(ethoxymethyl)acetanilide; and 2-chloro-2'-methyl-6'-trifluoromethyl-N-(ethoxymethyl)acetanilide.

  已发现 2,4-二取代-5-噻唑羧酸及其衍生物可减少玉米、水稻和高粱植物因施用选自 N-氯乙酰基-N-(2,6-二乙基苯基)甘氨酸乙酯的乙酰胺类除草剂而受到的除草伤害；2-氯-2',3'-二甲基-N-(异丙基)乙酰苯胺； 2-氯-2',6'-二甲基-N-(1-吡唑甲基)乙酰苯胺； 2-氯-6'-三氟甲基-N-(异丙氧基甲基)乙酰苯胺；2-氯-2'-甲基-6'-三氟甲基-N-(异丙氧基甲基)乙酰苯胺2-氯-2'-甲基-6'-乙氧基-N-(丙氧基甲基)乙酰苯胺； 2-氯-2'-异丁氧基-6'-甲基-N-(丙氧基甲基)乙酰苯胺； 2-氯-2'-异丁氧基-6'-乙基-N-(乙氧基甲基)乙酰苯胺；以及 2-氯-2'-甲基-6'-三氟甲基-N-(乙氧基甲基)乙酰苯胺。
• 3,5-Bis (trifluoromethyl) phenoxy carboxylic acids and derivatives thereof
  申请人：MONSANTO COMPANY

  公开号：EP0088066A1

  公开（公告）日：1983-09-07

  3,5-Bis (trifluoromethyl)phenoxy carboxylic acids and derivatives thereof have been found to reduce herbicidal injury of certain food crops, especially grain sorghum, due to the application thereto of herbicides that kill or control weeds that impede the yield of the crops.

  研究发现，3,5-双（三氟甲基）苯氧基羧酸及其衍生物可减少某些粮食作物（尤其是谷物高粱）因施用除草剂而受到的除草伤害，这些除草剂可杀死或控制妨碍作物产量的杂草。
• In vitro method to detect allergic reactions to low molecular weight chemicals
  申请人：Monsanto Company

  公开号：EP0265411A2

  公开（公告）日：1988-04-27

  This invention relates to the use of IgE sensitized basophiles and mast cells in in vitro tests to determine histamine release when challenged with small molecular weight chemical haptens conjugated to protein, e.g., human serum albumin.

  本发明涉及在体外试验中使用对 IgE 敏感的嗜碱性细胞和肥大细胞，以确定它们在受到与蛋白质（如人血清白蛋白）共轭的小分子量化学触杀素挑战时的组胺释放量。