(2E)-2-[(3E)-4-(furan-2-yl)but-3-en-2-ylidene]hydrazinecarboximidamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: (2E)-2-[(3E)-4-(furan-2-yl)but-3-en-2-ylidene]hydrazinecarboximidamide
• 英文别名: 2-[(E)-[(E)-4-(furan-2-yl)but-3-en-2-ylidene]amino]guanidine
• 化学式: C₉H₁₂N₄O
• 分子量: 192.22
• InChiKey: FFWSLJNMVAQYRJ-RKEQOFPCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  89.9
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• ANTIBIOTIC COMPOUNDS THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS
  申请人：The Board of Regents of the University of Texas System

  公开号：US20160220510A1

  公开（公告）日：2016-08-04

  An aminoacylation/translation (AIT) system based on the protein synthesis system from the pathogen Pseudomonas aeruginosa , was used to screen chemical compounds for identifying inhibitors of protein synthesis. This system includes elongation factors: EF-Tu, EF-Ts and EF-G, aminoacyl tRNA synthetase (aaRS) specific for phenylalanine, PheRS, and ribosomes isolated from cultures of Pseudomonas aeruginosa . Compounds identified using this assay have been shown to contain broad spectrum activity against both Gram+ and Gram− pathogens. Methods of using the identified compounds, as well as derivatives and analogues of these compounds, as antimicrobial agents against bacterial infections are described.