[1,1'-联苯]-2,3',4-三醇 | 4190-05-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: [1,1'-联苯]-2,3',4-三醇
• 英文名称: 2,3',4-Trihydroxybiphenyl
• 英文别名: (1,1'-biphenyl)-2,3',4-triol；biphenyl-2,4,3'-triol；4-(5-hydroxyphenyl)benzene-1,3-diol；[1,1'-Biphenyl]-2,3',4-triol；4-(3-hydroxyphenyl)benzene-1,3-diol
• CAS: 4190-05-0
• 化学式: C₁₂H₁₀O₃
• 分子量: 202.21
• InChiKey: HYFWTVWZCZMWEZ-UHFFFAOYSA-N

物化性质

• 熔点：
  136-136.5 °C
• 沸点：
  461.7±24.0 °C(Predicted)
• 密度：
  1.347±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2907299090

文献信息

• 1,3-Dihydroxybenzene derivatives and colorants containing said compounds
  申请人：——

  公开号：US20040016063A1

  公开（公告）日：2004-01-29

  1,3-Dihydroxybenzene derivatives of general formula (I) or (Ia) or physiologically tolerated, water-soluble thereof 1 wherein R′1 denotes substituted pyridyl group, a pyrimidyl group, a group of formula (IIa) or (IIIa) 2 and the dyeing agents for keratin fibers containing these compounds.

  一般式(I)或(Ia)的1,3-二羟基苯衍生物，或其生理耐受性、水溶性的衍生物，其中R′1代表取代吡啶基、嘧啶基、式(IIa)或(IIIa)的基团，以及含有这些化合物的角蛋白纤维染料剂。
• SERIES OF SKIN WHITENING (LIGHTENING) COMPOUNDS
  申请人：Nandy Sandip K.

  公开号：US20100016347A1

  公开（公告）日：2010-01-21

  The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.

  本发明涉及酪氨酸酶抑制剂，包含此类酪氨酸酶抑制剂的药物组合物，以及制备和使用这些药物的方法。具体而言，本发明包括至少一种2,4-二羟基苯类似物组成的物质组合物，这些组合物抑制酪氨酸酶的活性并抑制黑色素的过度产生。
• SERIES OF SKIN-WHITENING (LIGHTENING) COMPOUNDS
  申请人：Unigen, Inc.

  公开号：US20160083322A1

  公开（公告）日：2016-03-24

  The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.

  本发明涉及酪氨酸酶抑制剂、包含这种酪氨酸酶抑制剂的药物组合物以及制备和使用它们的方法。具体而言，本发明包括由至少一种2,4-二羟基苯类似物组成的物质组合物，其抑制酪氨酸酶活性并抑制黑色素的过度生产。
• Process for preparing hydroxyflavan compounds
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0688770A2

  公开（公告）日：1995-12-27

  A process for preparing a hydroxyflavan compound which comprises reacting a polyhydric phenol compound of formula (2): wherein at least one of W, X, Y and Z is hydroxy; with a ketone in the presence of (i) an acid catalyst and (ii) water and/or a seed crystal, using an organic solvent which is insoluble in water, produces the hydroxyflavan compound in high yield and with high selectivity while maintaining high conversion of the polyhydric phenol.

  一种制备羟基黄烷化合物的工艺，包括使式（2）的多水酚化合物发生反应： 其中 其中 W、X、Y 和 Z 中至少有一个是羟基； 与酮在(i)酸催化剂和(ii)水和/或籽晶存在下，使用不溶于水的有机溶剂，以高收率和高选择性生产羟基黄烷化合物，同时保持多氢苯酚的高转化率。
• Series of skin whitening (lightening) compounds
  申请人：Unigen, Inc.

  公开号：US10259764B2

  公开（公告）日：2019-04-16

  The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.

  本发明涉及酪氨酸酶抑制剂、包含这种酪氨酸酶抑制剂的药物组合物以及制造和使用这些药物组合物的方法。具体地说，本发明包括由至少一种 2,4-二羟基苯类似物组成的物质组合物，这种物质组合物能抑制酪氨酸酶的活性，并能抑制黑色素的过度生成。