(S)-5-((Aminoiminomethyl)amino)-2-(((4-methylphenyl)sulfonyl)amino)pentanamide | 2788-82-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-5-((Aminoiminomethyl)amino)-2-(((4-methylphenyl)sulfonyl)amino)pentanamide
• 英文别名: (2S)-5-(diaminomethylideneamino)-2-[(4-methylphenyl)sulfonylamino]pentanamide
• CAS: 2788-82-1
• 化学式: C₁₃H₂₁N₅O₃S
• 分子量: 327.41
• InChiKey: BCQIMMGLHQSLBH-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  162
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Dendritic chemiluminescent substrates
  申请人：——

  公开号：US20020155523A1

  公开（公告）日：2002-10-24

  Chemiluminescent substrate delivery systems comprising a conjugate a dendrimer and at least one chemiluminescent substrate are provided. The substrate delivery systems can also include a chemiluminescence enhancer. The dendrimer/chemiluminescent substrate conjugates can be used in kits including an enzyme capable of activating the chemiluminescent substrate to produce a peroxygenated intermediate that decomposes to produce light. The dendrimer/chemiluminescent substrate conjugates can be used in assays to detect the presence of an analyte (e.g., an enzyme, an antibody, an antigen or a nucleic acid) in a sample.

  提供了一种包括树状分子和至少一种化学发光底物的共轭物的化学发光底物传递系统。底物传递系统还可以包括一种化学发光增强剂。树状分子/化学发光底物共轭物可以用于包括能够激活化学发光底物以产生过氧化中间体并分解产生光的酶的试剂盒中。树状分子/化学发光底物共轭物可以用于检测样品中的分析物（例如酶、抗体、抗原或核酸）的存在的测定中。
• Cell Permeable Inhibitors of Anaphase Promoting Complex
  申请人：King Randall

  公开号：US20130230458A1

  公开（公告）日：2013-09-05

  The invention provides compositions and methods for treating cell cycle disorders. Compositions of the invention include proTAME, a prodrug analog of TAME, and, optionally, one or more therapeutic agents.

  本发明提供了用于治疗细胞周期紊乱的组合物和方法。本发明的组合物包括proTAME，TAME的前药类似物，以及一个或多个治疗剂（可选）。
• CELL PERMEABLE INHIBITORS OF ANAPHASE PROMOTING COMPLEX
  申请人：President and Fellows of Harvard College

  公开号：US20150328214A1

  公开（公告）日：2015-11-19

  The disclosure provides compositions and methods for treating cell cycle disorders. Compositions of the disclosure include proTAME, a prodrug analog of TAME and apcin, the combination of which inhibits an activity or function of the anaphase promoting complex (APC) by a synergistic mechanism.

  本公开提供了用于治疗细胞周期紊乱的组合物和方法。本公开的组合物包括proTAME和aPCin，它们的组合通过协同作用机制抑制负责有丝分裂后期促进复合物（APC）的活性或功能。其中，proTAME是TAME的前药类似物。
• Synthesis of 1,2-dioxetanes and intermediates therefor
  申请人：TROPIX, INC.

  公开号：EP0582317A2

  公开（公告）日：1994-02-09

  Compounds having formula (I), wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C₁₋₂₀ alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (e.g., m-phenylene), produced by reacting a compound having formula (II) with an R-ylating agent (e.g., R₂SO₄) in the presence of an alkali metal alkoxide in a polar aprotic solvent. Also, compounds having formula (III) are produced by reacting a compound having formula (IV) with formula (V), wherein X is an electronegative leaving group (e.g., a halogen anion such as chloride ion) in the presence of a Lewis base (e.g., a trialkyl-amine) dissolved in an aprotic organic solvent (e.g., benzene or toluene). Also, compounds having formula (VI) are produced by reacting a compound of formula (VII) with a tetra-O-acylated-O-hexopyranoside halide, then hydrolysing off the protective acyl groups. The aforementioned compounds and procedures are useful in the synthesis of enzyme-cleavable 1,2-dioxetane ring systems that can serve as members of a binding pair employed, for example, in chemiluminescent immunoassays, DNA probe assays, and direct assays for an enzyme.

  具有式 (I) 的化合物，其中 T 是亚多环烷基（如亚金刚烷-2-基）；R 是 C₁₋₂₀烷基、芳基或环烷基；以及 Y 是荧光发色团（如间苯二酚）、间苯二酚），通过在极性钝化溶剂中，在碱金属烷氧化物存在下，使具有式（II）的化合物与 R-酰化剂（如 R₂SO₄）反应制得。此外，具有式（III）的化合物是通过具有式（IV）的化合物与式（V）反应制得的，其中 X 为电负性离去基团（如卤素阴离子，如氯离子），反应条件为路易斯碱（如三烷基胺）溶于无极性有机溶剂（如苯或甲苯）中。此外，具有式（VI）的化合物是通过式（VII）的化合物与四-O-酰化-O-吡喃己苷卤化物反应，然后水解掉保护酰基而制得的。上述化合物和程序可用于合成可被酶清除的 1，2-二氧杂环烷环系统，这些环系统可作为例如化学发光免疫测定、DNA 探针测定和酶的直接测定中使用的结合对的成员。
• Improved chemiluminescent 1,2-dioxetanes
  申请人：TROPIX, INC.

  公开号：EP1120422A1

  公开（公告）日：2001-08-01

  Novel 1,2-dioxetanes with improved chemiluminescent properties, such as signal intensity, S/N ratio, T½, etc. are provided by spiroadamantyl 1,2-dioxetanes, wherein the remaining carbon atom of the ring bears an alkoxy, aryloxy, or arylalkoxy substituent, and either a phenyl or naphthyl ring, this aromatic ring bearing, at the meta position on the phenyl group, or a nonconjugated position on the naphthyl ring,an OX moiety wherein X is an enzyme-cleavable group, which when removed from the dioxetane, leaves the oxyanion which decomposes with chemiluminescence, the aryl ring further bearing an electron-active substituent Z. The nature and placement of the Z substituent, at a position not adjacent the point of attachment to the dioxetane ring, strongly influences the properties of the dioxetane. Assays, as well as kits for the performance of those assays, include the dioxetane, an enzyme capable of cleaving the X group, and in certain cases, membranes and chemiluminescent enhancement agents.

  新型 1,2-二氧杂环丁烷具有更好的化学发光特性，如信号强度、信噪比、T½ 等。新型 1,2-二氧杂环丁烷具有更好的化学发光性能，如信号强度、信噪比、T½ 等、或萘环上的非共轭位置上有一个 OX 分子，其中 X 是一个可被酶水解的基团，当它从二氧杂环烷中去除时，会留下氧阴离子，氧阴离子在化学发光作用下分解，芳基环上还带有一个电子活性取代基 Z。Z 取代基的性质和位置（与二氧杂环的连接点不相邻）对二氧杂环的性质有很大影响。检测方法以及进行这些检测的试剂盒包括二氧杂环丁烷、能够裂解 X 基的酶、以及在某些情况下的膜和化学发光增强剂。