3-hydrazino-2-methylpropanenitrile | 352-16-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-hydrazino-2-methylpropanenitrile
• 英文别名: 3-hydrazino-2-methylpropionitrile；3-Hydrazino-2-methyl-propionitril；3-Hydrazinyl-2-methylpropanenitrile
• CAS: 352-16-9
• 化学式: C₄H₉N₃
• mdl: MFCD22053192
• 分子量: 99.1356
• InChiKey: FDEPXCBPWPUHGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  61.8
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  3-hydrazino-2-methylpropanenitrile 、 丙酮 反应 24.0h， 生成 2-methyl-3-<(1-methylethylidene)hydrazino>propanenitrile
  参考文献：
  名称：

  Hydroxyalkylation with .alpha.-hydroperoxydiazenes. Alcohols from olefins and carbonyl compounds from enol ethers

  摘要：

  DOI：

  10.1021/jo00176a023
• 作为产物：
  描述：

  甲基丙烯腈 在 肼 作用下， 生成 3-hydrazino-2-methylpropanenitrile
  参考文献：
  名称：

  Convenient thermal sources of .beta.-cyanoalkyl radicals from .alpha.-hydroxydiazenes

  摘要：

  DOI：

  10.1021/ja00391a063

文献信息

• Notes- Synthesis and Some Reactions of 1,1-Bis(2-cyanoethyl)hydrazine.
  作者：John Lynn

  DOI：10.1021/jo01065a617

  日期：1961.6
• Convenient thermal sources of .beta.-cyanoalkyl radicals from .alpha.-hydroxydiazenes
  作者：Avtar S. Nazran、John Warkentin

  DOI：10.1021/ja00391a063

  日期：1981.1
• Selective and potent monoamine oxidase type B inhibitors: substituted semicarbazones and acylhydrazones of aromatic aldehydes and ketones
  作者：S Bernard、C Paillat、T Oddos、M Seman、R Milcent

  DOI：10.1016/0223-5234(96)88258-4

  日期：1995.1

  The synthesis and the evaluation of the monoamine oxidase A and B inhibitory activities of 21 new substituted acylhydrazones of various aromatic aldehydes and 4-(benzyloxy)acetophenone, and four substituted semicarbazones of benzaldehyde and 4-(benzyloxy)benzaldehyde, are described. The 4-(benzyloxy)phenyl group contributing to a high lipophilicity led to the most active compounds. One of these, compound 3g (IC50 = 3 nM, MAO A/MAO B selectivity > 33 000), was found to act as a reversible and probably tight-binding inhibitor. The studied acyclic hydrazones and semicarbazones are structurally related to other reversible and potent inhibitors, eg, heterocyclic compounds such as 1,3,4-oxadiazol-2(3H)-one derivatives in which the hydrazono group is intracyclic. Some of these new inhibitors might find use in the symptomatic treatment of neurodegenerative processes.
• OSEI-TWUM, E. Y.;MCCALLION, DOUG;NAZRAN, A. S.;PANICUCCI, R.;RISBOOD, P. +, J. ORG. CHEM., 1984, 49, N 2, 336-342
  作者：OSEI-TWUM, E. Y.、MCCALLION, DOUG、NAZRAN, A. S.、PANICUCCI, R.、RISBOOD, P. +

  DOI：——

  日期：——
• ELNAGDI M. H.; FAHMY S. M.; ELMOGHAYAR M. R. H.; ILIAS M. A. M., Z. NATURFORSCH. <ZENB-AX>, 1975, 30B, NO 9-10, 778-783
  作者：ELNAGDI M. H.、 FAHMY S. M.、 ELMOGHAYAR M. R. H.、 ILIAS M. A. M.

  DOI：——

  日期：——