5-Methyl-4-propan-2-ylhex-5-enenitrile | 365978-53-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-Methyl-4-propan-2-ylhex-5-enenitrile
• 英文别名: 5-methyl-4-propan-2-ylhex-5-enenitrile
• CAS: 365978-53-6
• 化学式: C₁₀H₁₇N
• 分子量: 151.252
• InChiKey: RDAYDKLLAXGXJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-Methyl-4-propan-2-ylhex-5-enenitrile 在 二异丁基氢化铝 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以83%的产率得到5-Methyl-4-propan-2-ylhex-5-enal
  参考文献：
  名称：

  Stereoselective synthesis of the bicyclo[5.3.0]decane portion of the diterpene antibiotic guanacastepene using a pyrylium-ylide [5+2] cycloaddition reaction

  摘要：

  Treatment of 14 with Ac2O/Et3N resulted in [5+2] cyclization to give 2, which was further elaborated into 20, thus establishing the required stereochemistry in the top-half of guanacastepene 1. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00851-6
• 作为产物：
  描述：

  甲基环戊烯醇酮 在 copper(l) iodide 吡啶 、 2,6-二甲基吡啶 、 五氯化磷 、 氯化铵 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 为溶剂， 反应 25.25h， 生成 5-Methyl-4-propan-2-ylhex-5-enenitrile
  参考文献：
  名称：

  Stereoselective synthesis of the bicyclo[5.3.0]decane portion of the diterpene antibiotic guanacastepene using a pyrylium-ylide [5+2] cycloaddition reaction

  摘要：

  Treatment of 14 with Ac2O/Et3N resulted in [5+2] cyclization to give 2, which was further elaborated into 20, thus establishing the required stereochemistry in the top-half of guanacastepene 1. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00851-6

文献信息

• Stereoselective synthesis of the bicyclo[5.3.0]decane portion of the diterpene antibiotic guanacastepene using a pyrylium-ylide [5+2] cycloaddition reaction
  作者：Philip Magnus、Michael J Waring、Cyril Ollivier、Vince Lynch

  DOI：10.1016/s0040-4039(01)00851-6

  日期：2001.7

  Treatment of 14 with Ac2O/Et3N resulted in [5+2] cyclization to give 2, which was further elaborated into 20, thus establishing the required stereochemistry in the top-half of guanacastepene 1. (C) 2001 Elsevier Science Ltd. All rights reserved.