N-(4,4-bis-ethoxy-butyl)-glycine nitrile | 1006878-78-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(4,4-bis-ethoxy-butyl)-glycine nitrile
• 英文别名: N-(4,4-Bis-aethoxy-butyl)-glycin-nitril；2-(4,4-Diethoxybutylamino)acetonitrile；2-(4,4-diethoxybutylamino)acetonitrile
• CAS: 1006878-78-9
• 化学式: C₁₀H₂₀N₂O₂
• 分子量: 200.281
• InChiKey: DHIPDCQOIPTHGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  54.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  piperidin-1-yl(pyridin-3-yl)methanone 、 N-(4,4-bis-ethoxy-butyl)-glycine nitrile 在 2,2,6,6-四甲基哌啶 、 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 以69%的产率得到2-(4,4-diethoxybutyl)-1H-pyrrolo[3,4-c]pyridin-3-one
  参考文献：
  名称：

  Aminomethylation of lithiated nicotinamide: access to new pyridolactams

  摘要：

  New 2,3-dihydropyrrolopyridinones were conveniently prepared by trapping lithiated pyridine carboxamides, with highly reactive formimines. In this Letter, we report that a wide range of N-functionalised compounds can be synthesised in one step by this process, allowing the presence of ethers, acetals or ester moieties. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.109
• 作为产物：
  描述：

  4-氨基丁醛缩二乙醇 、 氯乙腈 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以63%的产率得到N-(4,4-bis-ethoxy-butyl)-glycine nitrile
  参考文献：
  名称：

  Aminomethylation of lithiated nicotinamide: access to new pyridolactams

  摘要：

  New 2,3-dihydropyrrolopyridinones were conveniently prepared by trapping lithiated pyridine carboxamides, with highly reactive formimines. In this Letter, we report that a wide range of N-functionalised compounds can be synthesised in one step by this process, allowing the presence of ethers, acetals or ester moieties. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.109

文献信息

• King et al., Journal of the Chemical Society, 1951, p. 239,242
  作者：King et al.

  DOI：——

  日期：——
• Aminomethylation of lithiated nicotinamide: access to new pyridolactams
  作者：Emilie Prieur、Rabah Azzouz、Geoffrey Deguest、Corinne Fruit、Laurent Bischoff、Francis Marsais

  DOI：10.1016/j.tetlet.2007.11.109

  日期：2008.1

  New 2,3-dihydropyrrolopyridinones were conveniently prepared by trapping lithiated pyridine carboxamides, with highly reactive formimines. In this Letter, we report that a wide range of N-functionalised compounds can be synthesised in one step by this process, allowing the presence of ethers, acetals or ester moieties. (C) 2007 Elsevier Ltd. All rights reserved.