(5E)-5-benzylidene-3-methyl-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (5E)-5-benzylidene-3-methyl-1,3-thiazolidine-2,4-dione
• 化学式: C₁₁H₉NO₂S
• 分子量: 219.26
• InChiKey: PXSCNCMWGXHYFD-VQHVLOKHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  62.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Heterocyclic derivatives as modulators of ion channels
  申请人：Martinborough Esther

  公开号：US20080027067A1

  公开（公告）日：2008-01-31

  The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及用作离子通道抑制剂的杂环衍生物。该发明还提供了包括本发明化合物的药用可接受组合物，以及使用这些组合物治疗各种疾病的方法。
• Compositions useful as inhibitors of voltage-gated sodium channels
  申请人：Gonzalez E. Jesus

  公开号：US20060025415A1

  公开（公告）日：2006-02-02

  The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及用作电压门控钠通道抑制剂的化合物。本发明还提供了包含本发明化合物的药学上可接受的组合物以及使用这些组合物治疗各种疾病的方法。
• Bicyclic derivatives as modulators of ion channels
  申请人：Kawatkar Aarti S.

  公开号：US20090012117A1

  公开（公告）日：2009-01-08

  Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:

  具有化学式（I）的双环衍生物及其组合物可用作离子通道拮抗剂。
• Indane Derivatives as Modulators of ION Channels
  申请人：Neubert Timothy

  公开号：US20090326023A1

  公开（公告）日：2009-12-31

  The present invention relates to indane derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及一种用于离子通道抑制剂的茚烷衍生物。本发明还提供了包括本发明化合物的药学上可接受的组合物以及使用这些组合物治疗各种疾病的方法。
• Biphenyl derivatives as modulators of voltage gated ion channels
  申请人：Martinborough Esther

  公开号：US20080113990A1

  公开（公告）日：2008-05-15

  Biphenyl derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.

  本文披露了作为离子通道拮抗剂有用的联苯衍生物。其组成物对于治疗或缓解与疼痛有关的疾病条件有用。