蓖麻醇酸酰胺MEA | 106-16-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 蓖麻醇酸酰胺MEA
• 英文名称: (Z)-(R)-12-hydroxyoctadec-9-enoic acid (2-hydroxyethyl)amide
• 英文别名: N-(2-hydroxyethyl)-(12R)-hydroxyoctadec-(9Z)-enamide；(12R,9Z)-N-(2-hydroxyethyl)-12-hydroxyoctadec-9-enamide；9-Octadecenamide, 12-hydroxy-N-(2-hydroxyethyl)-, (9Z,12R)-；(Z,12R)-12-hydroxy-N-(2-hydroxyethyl)octadec-9-enamide
• CAS: 106-16-1
• 化学式: C₂₀H₃₉NO₃
• 分子量: 341.535
• InChiKey: JYDIHAYTECQGQK-UZRURVBFSA-N

物化性质

• 熔点：
  58-59 °C
• 沸点：
  536.2±40.0 °C(Predicted)
• 密度：
  0.965±0.06 g/cm3(Predicted)
• LogP：
  4.363 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  蓖麻醇酸酰胺MEA 、 乙酸酐 在 吡啶 作用下， 以 苯 为溶剂， 反应 24.0h， 以95%的产率得到acetic acid 2-((Z)-(R)-12-acetoxy-octadec-9-enoylamino)ethyl ester
  参考文献：
  名称：

  （R）-和（S）-蓖麻油酰胺及其乙酸酯的合成和细胞毒性。

  摘要：

  环保，无溶剂的合成（R）和（S的方法）-蓖麻油酰胺已被开发出来。从蓖麻油酸甲酯和吡咯烷或乙醇胺开始，可获得相应的酰胺，产率为83-88％。在12种合成的蓖麻油酸衍生物中，包括起始的甲基酯，酰胺及其乙酸酯，首次获得了9种化合物并进行了测试。对蓖麻油酸衍生物的细胞毒性研究表明，甲酯是最不具细胞毒性的化合物，其结构的改变导致所得产物对癌细胞和正常淋巴细胞的细胞毒性增加。乙醇胺衍生的酰胺的两种对映体均显示出最有希望的抗癌潜力。

  DOI：

  10.1002/chir.22733
• 作为产物：
  描述：

  蓖麻油酸 在 硫酸 作用下， 以 乙腈 为溶剂， 反应 24.0h， 生成 蓖麻醇酸酰胺MEA
  参考文献：
  名称：

  Antiproliferative activity of synthetic fatty acid amides from renewable resources

  摘要：

  In the work, the in vitro antiproliferative activity of a series of synthetic fatty acid amides were investigated in seven cancer cell lines. The study revealed that most of the compounds showed antiproliferative activity against tested tumor cell lines, mainly on human glioma cells (U251) and human ovarian cancer cells with a multiple drug-resistant phenotype (NCI-ADR/RES). In addition, the fatty methyl benzylamide derived from ricinoleic acid (with the fatty acid obtained from castor oil, a renewable resource) showed a high selectivity with potent growth inhibition and cell death for the glioma cell line-the most aggressive CNS cancer. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2014.11.019

文献信息

• Synthesis of (<i>R</i>)- and (<i>S</i>)-Ricinoleic Acid Amides and Evaluation of Their Antimicrobial Activity
  作者：Sylwia Matysiak、Julia Zabielska、Józef Kula、Alina Kunicka-Styczyńska

  DOI：10.1002/aocs.12013

  日期：2018.1

  fatty acid amides derived from (R)‐ and (S)‐ricinoleic acid and 4 cyclic and acyclic amines were synthesized in a proecological solvent‐free process with yields ranging from 43 to 88%. All S‐configured compounds and both enantiomers of amide with 2‐amino‐2‐methyl‐1‐propanol were obtained and studied in terms of biological activity for the first time. The evaluation of antimicrobial activity of (R)‐ and

  在无保护性溶剂的过程中合成了一系列衍生自（R）和（S）蓖麻油酸的脂肪酸酰胺和4个环胺和无环胺，收率范围为43％至88％。首次获得了所有S构型的化合物以及酰胺与2-氨基-2-甲基-1-丙醇的两种对映异构体，并首次就生物学活性进行了研究。（R）和（S）-蓖麻油酸衍生物对代表革兰氏阴性和革兰氏阳性细菌，酵母和霉菌的13种不同微生物的抗菌活性评估显示出对革兰氏阳性细菌特别是黄球菌和微球菌的显着抑制活性。枯草芽孢杆菌，并针对选定的霉菌。乙醇胺和吡咯烷衍生的酰胺显示出最有希望的抗菌和抗霉菌潜力。蓖麻油酸和吡咯烷的衍生物对选择的两种霉菌，巴西曲霉和扩张青霉的活性最高。而且，R-构型的类似物对枯草芽孢杆菌最有效。蓖麻油酸与乙醇胺的酰胺对金黄色葡萄球菌显示出显着的潜力，这使它们与该细菌具有很高抗性的其余测试衍生物区分开来。
• Developing powder composition containing a fluorine-modified alkyl siloxane
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0098112A2

  公开（公告）日：1984-01-11

  A mono-component toner powder composition which exhibits reduced sensitivity to machine conditions and provides copies whose images are sharply defined having substantially reduced backgrounding and good image density. The composition comprises a plurality of discrete particles each comprising a thermoplastic binder, a magnetically responsive material and carbon black, in which: (a) the binder comprises from 40 to 70 weight percent of the composition and is selected from the group consisting of (i) polyester resins, (ii) copolymers of styrene monomers and at least one monomer selected from acrylate and methacrylate monomers, (iii) a wax component having a melting point in the range of from 45 to 150°C, and (iv) a blend of the wax component and a thermoplastic organic resin, in which the weight ratio of the wax component to the thermoplastic organic resin is in the range of from 1:0.1 to 1:1; (b) the magnetically responsive material comprises from 30 to 60 weight percent of the composition, the magnetically responsive material being dispersed in the binder; (c) from 0.05 to 2 weight percent of the composition of a fluorine-modified alkyl siloxane dispersed in the binder, and (d) the carbon black comprises from 0.005 to 0.3 weight percent of the composition and is attached to the exterior surface of the particles thereof.

  一种单组分调色剂粉末组合物，可降低对机器条件的敏感性，并可提供图像清晰的复印件，同时大幅降低背景干扰和良好的图像密度。该组合物由多个离散颗粒组成，每个颗粒都包含热塑性粘合剂、磁响应材料和炭黑，其中： (a) 粘结剂占组合物的 40%至 70%，选自以下组别：(i) 聚酯树脂；(ii) 苯乙烯单体和至少一种选自丙烯酸酯和甲基丙烯酸酯单体的共聚物；(iii) 熔点在 45 至 150°C 范围内的蜡组分；(iv) 蜡组分和热塑性有机树脂的混合物，其中蜡组分和热塑性有机树脂的重量比在 1:0.1 至 1:1； (b) 磁响应材料占组合物的 30%至 60%，磁响应材料分散在粘结剂中； (c) 分散在粘合剂中的氟改性烷基硅氧烷占组合物的 0.05%至 2%，以及 (d) 炭黑占该组合物的 0.005 至 0.3 重量百分比，并附着在其颗粒的外表面。
• Preparation method for shear-thinning water-based ball-point pen inks, shear-thinning water-based ball-point pen ink compositions, and ball-point pens employing the same
  申请人：The Pilot Ink CO., Ltd.

  公开号：EP0787779A2

  公开（公告）日：1997-08-06

  A shear-thinning water-based ball-point pen ink composition comprising from 1% by weight to 35% by weight of a colorant, from 2% by weight to 35% by weight of a water-soluble polar solvent, from 1% by weight to 30% by weight of a nonionic surface active agent having an HLB value within the range of from 8 to 12, and the balance being water and adjusting additives, and having a viscosity within the range of from 25 mPa.s to 160 mPa.s (a value at the number of revolution of 100 rpm in an EM type rotational viscometer, 25°C) and a shear thinning index within the range of from 0.1 to 0.6; the nonionic surface active agent having a mixed phase comprising a phase standing dispersed in the form of fine particles and a phase standing dissolved in a molecular state. A method for preparing the ink composition and a ball-point pen employing the ink composition are also disclosed.

  一种剪切稀化型水基圆珠笔墨水组合物，包括重量百分比为 1%至 35%的着色剂、重量百分比为 2%至 35%的水溶性极性溶剂、重量百分比为 1%至 30%的 HLB 值在 8 至 12 范围内的非离子表面活性剂，余量为水和调节添加剂。s至 160 mPa.s（在 EM 型旋转粘度计中，转速为 100 rpm，温度为 25℃时的值），剪切稀化指数在 0.1 至 0.6 之间；非离子表面活性剂具有混合相，混合相包括以细颗粒形式分散的相和以分子状态溶解的相。 此外，还公开了制备该墨水组合物的方法和使用该墨水组合物的圆珠笔。
• Conditioning cream color base having good color deposition properties.
  申请人：L'Oréal

  公开号：EP1852103A2

  公开（公告）日：2007-11-07

  The present invention is directed to a process and composition for dyeing hair, the composition containing:(a) greater than 10% by weight, based on the weight of the composition, of at least one fatty acid alkanolamide;(b) at least one C6-C36 dicarboxylic acid;(c) at least one water soluble base capable of reacting with the at least one C6-C36 dicarboxylic acid (b) to form a soap;(d) at least one conditioning polymer; (e) at least one oxidation dye; and(f) optionally, at least one oxidizing agent, wherein the composition is in cream form.

  本发明涉及一种染发工艺和组合物，该组合物含有(a) 至少一种脂肪酸烷醇酰胺；(b) 至少一种 C6-C36 二羧酸；(c) 至少一种能与至少一种 C6-C36 二羧酸 (b) 反应形成皂的水溶性碱；(d) 至少一种调理聚合物；(e) 至少一种氧化染料；以及(f) 可选地，至少一种氧化剂，其中该组合物为膏状。
• POLYLACTIC ACID HEAT-RESISTANT SHEET
  申请人：UNITIKA LTD.

  公开号：EP2025713A1

  公开（公告）日：2009-02-18

  Disclosed is a polylactic acid based heat-resistant sheet suitable for molding. The polylactic acid based heat-resistant sheet containing 50 to 95% by mass of a polylactic acid and 5 to 50% by mass of a polylactic acid-based copolymer which contains 30 to 70 % by mole of a lactic acid component. The polylactic acid based heat-resistant sheet has a crystallization peak temperature of 60 to 120°C, a heat quantity of crystallization of 10 to 25 J/g, a melting point of 160°C or higher and a heat quantity of crystal fusion of 15 to 40 J/g, as measured with a differential scanning calorimeter at a temperature increase rate of 20°C/min.

  本发明公开了一种适用于模塑的聚乳酸基耐热片材。这种聚乳酸基耐热片材含有 50%至 95%（按质量计）的聚乳酸和 5%至 50%（按质量计）的聚乳酸基共聚物，其中含有 30%至 70%（按摩尔计）的乳酸成分。聚乳酸基耐热片材的结晶峰值温度为 60 至 120°C，结晶热量为 10 至 25 焦耳/克，熔点为 160°C 或更高，晶体融合热量为 15 至 40 焦耳/克。