(2Z)-2-hydroxyimino-1-benzothiophen-3-one

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (2Z)-2-hydroxyimino-1-benzothiophen-3-one
• 化学式: C₈H₅NO₂S
• 分子量: 179.2
• InChiKey: TUKHPVUSNYULKR-HJWRWDBZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  75
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [DE] NEUE PYRIMIDIN-DERIVATE UND IHRE VERWENDUNG ALS PPAR-ALPHA-MODULATOREN<br/>[EN] NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE AS PPAR-ALPHA MODULATORS<br/>[FR] NOUVEAUX DERIVES DE PYRIMIDINE ET LEUR UTILISATION COMME MODULATEURS DE PPAR-ALPHA
  申请人：BAYER HEALTHCARE AG

  公开号：WO2006032384A1

  公开（公告）日：2006-03-30

  Die vorliegende Anmeldung betrifft neue Pyrimidin-Derivate der allgemeinen Formel (I), Verfahren zu ihrer Herstellung, ihre Verwendung zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, vorzugsweise zur Behandlung und/oder Prävention kardiovaskulärer Erkrankungen, insbesondere von Dyslipidämien, Arteriosklerose, Herzinsuffizienz, Thrombose und des metabolischen Syndroms.

  本申请涉及新的嘧啶衍生物，其一般公式为（I），其制备方法，其用于治疗和/或预防疾病的用途以及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/或预防心血管疾病，特别是脂质代谢异常、动脉粥样硬化、心力衰竭、血栓形成和代谢综合征。
• Reductive colorant for keratin fibres
  申请人：Wella Aktiengesellschaft

  公开号：EP1707187B1

  公开（公告）日：2007-08-01
• NEUE PYRIMIDIN-DERIVATE UND IHRE VERWENDUNG ALS PPAR-ALPHA-MODULATOREN
  申请人：Bayer HealthCare AG

  公开号：EP1797045A1

  公开（公告）日：2007-06-20
• Inhibitors of Dna Methylation in Tumor Cells
  申请人：Garcia Boy Regine

  公开号：US20080138329A1

  公开（公告）日：2008-06-12

  The present invention relates to compounds according to the general formula wherein the dotted lines denote a single bond which is optionally present, with 2 dotted lines denoting a double bond; wherein, in case no double bond is present and a free valence exists, this valence is occupied by H; and wherein the symbols have the meanings defined in the text, or a pharmaceutically acceptable salt thereof, and which lend themselves for the manufacture of drugs useful in the inhibtion of DNA methylation, the inhibition of DNA methyltransferases, and may therefore be useful for the manufacture of pharmaceuticals for the treatment of developmental disorders such as Prader-Willi-Syndrome, Angelman-Syndrome (Happy Puppet Syndrome), Beckwith-Wiedemann-Syndrome, and proliferative diseases, such as coronary restenosis and neoplastic diseases, particularly colon carcinoma, familiary adenomatous polyposis carcinoma and hereditary non-polyposis colorectal cancer, prostate carcinoma, melanoma, non-Hodgkin lymphoma, acute lymphatic leukemia (ALL), chronic lymphatic leukemia (CLL), acute myeolid leukemia (AML), chronic myeloid leukemia (CML), or hepatocellular carcinoma. These compounds may also be used for other applications including the induction of cellular differentiation, diagnosis, and the use in screening assays.
• [EN] REDUCTIVE COLORANT FOR KERATIN FIBRES<br/>[FR] SYSTEME REDUCTEUR POUR FIBRES DE KERATINE
  申请人：PROCTER & GAMBLE

  公开号：WO2006107595A1

  公开（公告）日：2006-10-12

  [EN] Agent for colouring keratin-containing fibres, in particular human hair, comprising a) ascorbic acid, b) at least one oxime compound and c) at least one reactive carbonyl compound, and method of colouring hair using this agent.
  [FR] La présente invention concerne un agent destiné à la coloration de fibres contenant de la kératine, en particulier les cheveux humains, lequel comprend a) de l'acide ascorbique ; b) au moins un composé oxime et c) au moins un composé carbonyle réactif ; l'invention concerne également un procédé de coloration des cheveux utilisant cet agent.