N-(2-dimethylaminoethyl)-N-(3-pyridyl)acetamide | 75329-41-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(2-dimethylaminoethyl)-N-(3-pyridyl)acetamide
• 英文别名: N-[2-(dimethylamino)ethyl]-N-pyridin-3-ylacetamide
• CAS: 75329-41-8
• 化学式: C₁₁H₁₇N₃O
• 分子量: 207.275
• InChiKey: MGIBJHKPBWZBQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  36.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2-dimethylaminoethyl)-N-(3-pyridyl)acetamide 、 N-(5-Chlor-<2>pyridyl)-N-(2-dimethylamino-ethyl)-acetamid 生成 N,N-dimethyl-N'-pyridin-3-ylethane-1,2-diamine
  参考文献：
  名称：

  Pyridinyl ureas and pharmaceutical use

  摘要：

  公式为##STR1##的化合物已被发现能够抑制哺乳动物物种的胃分泌。

  公开号：

  US04203988A1

文献信息

• Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers
  申请人：SYNTARGA BV

  公开号：US20170274090A1

  公开（公告）日：2017-09-28

  This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
• US4203988A
  申请人：——

  公开号：US4203988A

  公开（公告）日：1980-05-20
• [EN] NOVEL CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS<br/>[FR] NOUVEAUX CONJUGUÉS D'ANALOGUES DE CC-1065 ET LINKERS BIFONCTIONNELS
  申请人：SYNTARGA BV

  公开号：WO2011133039A2

  公开（公告）日：2011-10-27

  This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
• Pyridinyl ureas and pharmaceutical use
  申请人：Merck & Co., Inc.

  公开号：US04203988A1

  公开（公告）日：1980-05-20

  Compounds of the formula ##STR1## have been found to inhibit gastric secretion in mammalian species.

  公式为##STR1##的化合物已被发现能够抑制哺乳动物物种的胃分泌。