Phenyl methyl perchlorate | 20538-01-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phenyl methyl perchlorate
• 英文别名: benzyl perchlorate
• CAS: 20538-01-6
• 化学式: C₇H₇ClO₄
• 分子量: 190.583
• InChiKey: YXCSUWZAVULLSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲苯 在 四氧化氯 作用下， 生成 Phenyl methyl perchlorate
  参考文献：
  名称：

  Eberson, Lennart, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1980, vol. 34, # 7, p. 481 - 492

  摘要：

  DOI：

文献信息

• [EN] SYNTHETIC N-ACETYL-MURAMIC ACID DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS D'ACIDE MURAMIQUE N-ACÉTYLÉ SYNTHÉTIQUES ET LEURS UTILISATIONS
  申请人：UNIV DELAWARE

  公开号：WO2016172615A1

  公开（公告）日：2016-10-27

  The present invention provides N-acetyl-muramic acid (NAM) derivatives having Formula I, wherein Xa is selected from the group consisting of X1-X59, Ya is selected from the group consisting of H, monophosphate, uridine diphosphate and ethyl azide linker prepared from 2-azido-ethanol, and Za is selected from the group consisting of OH, an ethylene diamine coupled fluorophore, a peptide and a peptide with an ethylene diamine coupled fluorophore, wherein the peptide is selected from the group consisting of a monopeptide, a dipeptide, a tripeptide and a pentapeptide. Also provided are methods for synthesizing NAM derivatives and methods for modulating Nod2 in cells, modifying bacterial cell wall or modulating innate immune response by a subject to bacterial cells upon exposure to NAM derivatives.

  本发明提供具有式I的N-乙酰-壳聚糖酸（NAM）衍生物，其中Xa选自X1-X59组，Ya选自H、磷酸单酯、尿苷二磷酸和由2-叠氮乙醇制备的乙基叠氮连接剂组，Za选自OH、乙二胺偶联的荧光素、肽和乙二胺偶联的肽，其中肽选自单肽、二肽、三肽和五肽组。还提供了合成NAM衍生物的方法以及通过暴露于NAM衍生物后调节细胞中Nod2、修改细菌细胞壁或调节受试者对细菌细胞的固有免疫反应的方法。
• Synthetic N-acetyl-muramic acid derivatives and uses thereof
  申请人：Grimes Catherine Leimkuhler

  公开号：US10988508B2

  公开（公告）日：2021-04-27

  The present invention provides N-acetyl-muramic acid (NAM) derivatives having Formula I, wherein Xa is selected from the group consisting of X1-X59, Ya is selected from the group consisting of H, monophosphate, uridine diphosphate and ethyl azide linker prepared from 2-azido-ethanol, and Za is selected from the group consisting of OH, an ethylene diamine coupled fluorophore, a peptide and a peptide with an ethylene diamine coupled fluorophore, wherein the peptide is selected from the group consisting of a monopeptide, a dipeptide, a tripeptide and a pentapeptide. Also provided are methods for synthesizing NAM derivatives and methods for modulating Nod2 in cells, modifying bacterial cell wall or modulating innate immune response by a subject to bacterial cells upon exposure to NAM derivatives.

  本发明提供了具有式 I 的 N-乙酰基木氨酸（NAM）衍生物，其中 Xa 选自 X1-X59 所组成的组，Ya 选自 H、单磷酸、二磷酸尿苷和由 2-叠氮乙醇制备的乙基叠氮连接体所组成的组、Za选自由OH、乙二胺偶联荧光团、肽和带有乙二胺偶联荧光团的肽组成的组，其中肽选自由单肽、二肽、三肽和五肽组成的组。还提供了合成 NAM 衍生物的方法和用于调节细胞中的 Nod2、调节细菌细胞壁或调节受试者接触 NAM 衍生物后对细菌细胞的先天性免疫反应的方法。
• Process for manufacturing L-(-)-carnitine from a waste product having opposite configuration
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP0609643B1

  公开（公告）日：1996-07-24
• SYNTHETIC N-ACETYL-MURAMIC ACID DERIVATIVES AND USES THEREOF
  申请人：GRIMES Catherine Leimkuhler

  公开号：US20180298061A1

  公开（公告）日：2018-10-18

  The present invention provides N-acetyl-muramic acid (NAM) derivatives having Formula I, wherein Xa is selected from the group consisting of X1-X59, Ya is selected from the group consisting of H, monophosphate, uridine diphosphate and ethyl azide linker prepared from 2-azido-ethanol, and Za is selected from the group consisting of OH, an ethylene diamine coupled fluorophore, a peptide and a peptide with an ethylene diamine coupled fluorophore, wherein the peptide is selected from the group consisting of a monopeptide, a dipeptide, a tripeptide and a pentapeptide. Also provided are methods for synthesizing NAM derivatives and methods for modulating Nod2 in cells, modifying bacterial cell wall or modulating innate immune response by a subject to bacterial cells upon exposure to NAM derivatives.
• US4081450A
  申请人：——

  公开号：US4081450A

  公开（公告）日：1978-03-28