2,6-difluorophenylguanidine | 76635-23-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-difluorophenylguanidine
• 英文别名: N-(2,6-Difluorophenyl)-guanidine；2-(2,6-difluorophenyl)guanidine
• CAS: 76635-23-9
• 化学式: C₇H₇F₂N₃
• 分子量: 171.149
• InChiKey: RYEVBHAQZMEFTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• AMINOTHIAZOLE INHIBITORS OF CYCLIN DEPENDENT KINASES
  申请人：Bristol-Myers Squibb Co.

  公开号：EP1240153A1

  公开（公告）日：2002-09-18
• US3976643A
  申请人：——

  公开号：US3976643A

  公开（公告）日：1976-08-24
• [EN] AMINOTHIAZOLE INHIBITORS OF CYCLIN DEPENDENT KINASES<br/>[FR] INHIBITEURS AMINOTHIAZOLES DE KINASES DEPENDANTES DE LA CYCLINE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2001044217A1

  公开（公告）日：2001-06-21

  Compounds of formula (I) and pharmaceutically acceptable salts thereof. As used in formula (I), and throughout the specification, the symbols have the following meanings: R1 and R2 are independently hydrogen, fluorine or alkyl; R3 is aryl or heteroaryl, R4 has various meanings; R5 is hydrogen or alkyl; m is an integer of 0 to 2; and n is an integer of 1 to 3. The compounds of formula (I) are protein kinase inhibitors and are useful in the treatment and prevention of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of neurodegenerative diseases such as Alzheimer's diseases cardiovascular diseases, viral diseases and fungal diseases.