2-Propoxy-5-methyl-benzoesaeure | 93351-66-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Propoxy-5-methyl-benzoesaeure
• 英文别名: 5-methyl-2-propoxy-benzoic acid；5-Methyl-2-propoxy-benzoesaeure；2-propoxy-5-methylbenzoic acid；5-Methyl-2-propoxybenzoic acid
• CAS: 93351-66-7
• 化学式: C₁₁H₁₄O₃
• mdl: MFCD11901723
• 分子量: 194.23
• InChiKey: AGFPDQMSANRAMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] DISUBSTITUTED OCTAHY-DROPYRROLO [3,4-C] PYRROLES AS OREXIN RECEPTOR MODULATORS<br/>[FR] OCTAHYDROPYRROLO [3,4-C] PYRROLES DISUBSTITUÉS UTILISÉS COMME MODULATEURS DU RÉCEPTEUR DE L'OREXINE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2012145581A1

  公开（公告）日：2012-10-26

  Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.

  描述了二取代的八氢吡咯[3,4-c]吡咯化合物，这些化合物可用作促进睡眠素受体的调节剂。这些化合物可能在药物组合物和治疗由促进睡眠素活性介导的疾病状态、紊乱和病况的方法中有用，比如失眠。
• [EN] COMPOUNDS USEFUL AS INHIBITORS OF ALCAT 1<br/>[FR] COMPOSÉS UTILES EN TANT QU'INHIBITEURS D'ALCAT 1
  申请人：PERENNA PHARMACEUTICALS INC

  公开号：WO2018178304A1

  公开（公告）日：2018-10-04

  Inhibitors of ALCAT1 are described having the general formula: (I). These compounds offer a treatment for aging and age-related diseases.

  ALCAT1的抑制剂具有一般公式：(I)。这些化合物提供了治疗衰老和与年龄相关疾病的方法。
• Compositions and Methods for Treating Female Sexual Dysfunction
  申请人：Lee Andrew G.

  公开号：US20090264413A1

  公开（公告）日：2009-10-22

  This invention relates to methods, pharmaceutical compositions and kits useful in treating female sexual dysfunction and the use of an estrogen agonist/antagonist for the manufacture of a medicament for the treatment of female sexual dysfunction. The compositions are comprised of an estrogen agonist/antagonist as a first active ingredient and a cyclic guanosine 3′,5′-monophosphate elevator as a second active component and a pharmaceutically acceptable vehicle, carrier or diluent. The compositions and methods of treatment are effective while substantially reducing the concomitant liability of adverse effects associated with estrogen administration.

  本发明涉及用于治疗女性性功能障碍的方法、制药组合物和试剂盒，以及使用雌激素激动剂/拮抗剂制造治疗女性性功能障碍药物。该组合物包括雌激素激动剂/拮抗剂作为第一活性成分，环磷鸟苷3'-5'-单磷酸升高剂作为第二活性成分，以及药学上可接受的载体、载体或稀释剂。该组合物和治疗方法在显著减少雌激素给药相关的不良反应的同时具有有效性。
• DISUBSTITUTED OCTAHYDROPYRROLO [3,4-C] PYRROLES AS OREXIN RECEPTOR MODULATORS
  申请人：Letavic Michael A.

  公开号：US20140171430A1

  公开（公告）日：2014-06-19

  Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.

  本文介绍了双取代的八氢吡咯并[3,4-c]吡咯化合物，其可用作促进荷尔蒙受体的调节剂。这些化合物可以用于制备药物组合物，并用于治疗由荷尔蒙活性介导的疾病状态、紊乱和情况，如失眠等。
• Compounds useful as inhibitors of ALCAT 1
  申请人：PERENNA PHARMACEUTICALS, INC.

  公开号：US11208404B2

  公开（公告）日：2021-12-28

  Inhibitors of ALCAT1 are described having the general formula: (I). These compounds offer a treatment for aging and age-related diseases.

  ALCAT1 的抑制剂通式如下：(I).这些化合物可治疗衰老和与衰老有关的疾病。