2-Chloro-1-ethyl-4-(trifluoromethyl)benzene | 1369785-22-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Chloro-1-ethyl-4-(trifluoromethyl)benzene
• CAS: 1369785-22-7
• 化学式: C₉H₈ClF₃
• 分子量: 208.61
• InChiKey: OFLVFJLZMRAAQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] TRPV4 RECEPTOR LIGANDS<br/>[FR] LIGANDS DU RÉCEPTEUR DU TRPV4
  申请人：UNIV UTAH RES FOUND

  公开号：WO2021102314A1

  公开（公告）日：2021-05-27

  Described are receptor ligands of transient receptor potential cation channel subfamily V member 4 (TRPV4), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating ocular disorders.

  描述了转瞬性受体电位阳离子通道亚家族V成员4（TRPV4）的受体配体，包括这些化合物的药物组合物，以及使用这些化合物和组合物治疗眼部疾病的方法。
• [EN] GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAININ SUCH COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS ANTAGONISTES DU RÉCEPTEUR DU GLUCAGON, COMPOSITIONS CONTENANT DE TELS COMPOSÉS ET PROCÉDÉS D'UTILISATION
  申请人：MERCK SHARP & DOHME

  公开号：WO2010098948A1

  公开（公告）日：2010-09-02

  Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

  葡萄糖素受体拮抗剂化合物已被披露。这些化合物可用于治疗2型糖尿病及相关疾病。还包括药物组合物和治疗方法。
• HOMOPIPERONY LAMINE COMPOUND AND USE THEREOF
  申请人：SINOCHEM CORPORATION

  公开号：US20150225378A1

  公开（公告）日：2015-08-13

  The invention discloses a homopiperony lamine compound which has a structural general formula I as follows as shown in the specification: wherein definitions of substituents in the formula are as shown in the specification. The compound shown as the general formula I has broad-spectrum bactericidal and insecticidal activity in the field of agriculture. The compound shown as the general formula I has a good prevention effect on various germs such as cucumber downy mildew, wheat powdery mildew, puccinia sorghi, rice blast and cucumber gray mold, and particularly, still has the good prevention and control effect on the cucumber downy mildew, the puccinia sorghi and the wheat powdery mildew at a lower dosage. At the same time, a part of compound has better insecticidal activity, and can be used for preventing and controlling various insect pests such as diamondback moths, myzus persicae, armyworms and tetranychus cinabarinus boisdu.

  该发明公开了一种具有如下结构通式I的吗啡啶胺化合物，其中通式中的取代基定义如说明书所示。所示通式I的化合物在农业领域具有广谱的杀菌和杀虫活性。所示通式I的化合物对黄瓜霜霉病、小麦白粉病、玉米锈病、水稻稻瘟病和黄瓜灰霉病等各种细菌具有良好的防治效果，特别是在较低剂量下对黄瓜霜霉病、玉米锈病和小麦白粉病仍具有良好的防治效果。同时，部分化合物具有更好的杀虫活性，可用于预防和控制菜青虫、桃蚜、军虫和赤蜘蛛等各种昆虫害虫。
• PYRAZOLYL PYRIMIDINAMINE COMPOUND AND APPLICATION THEREOF
  申请人：SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD.

  公开号：US20160332991A1

  公开（公告）日：2016-11-17

  Disclosed are pyrazolyl pyrimidinamine compounds with structures as shown in Formula I: The definitions of each of the substituents can be seen in the description. The compounds of present invention have a broad spectrum of bactericidal, insecticidal and acaricidal activity, and have good control effect on downy mildew of cucumber, powdery mildew of wheat, corn rust, anthracnosis of cucumber and the like, and especially have better control effect on downy mildew of cucumber, powdery mildew of wheat and anthracnosis of cucumber. The compounds of present invention also show good insecticidal activity, part of the compounds, at very low doses, have excellent control effect on diseases caused by Plutella xylostella , armyworm, Myzus persicae, Tetranychus cinnabarinus etc.

  本发明揭示了具有如下式所示结构的吡唑基嘧啶胺化合物：每个取代基的定义可在说明书中看到。本发明的化合物具有广谱的杀菌、杀虫和杀螨活性，并且对黄瓜霜霉病、小麦白粉病、玉米锈病、黄瓜炭疽病等病害具有良好的控制效果，特别对黄瓜霜霉病、小麦白粉病和黄瓜炭疽病有更好的控制效果。本发明的化合物还表现出良好的杀虫活性，其中部分化合物在非常低剂量下对由小菜蛾、军虫、桃蚜、细毛螨等引起的疾病具有出色的控制效果。
• ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE
  申请人：Li Xiaoming

  公开号：US20080194545A1

  公开（公告）日：2008-08-14

  The present invention is directed to compounds of formula I, pharmaceutical compositions comprising the compounds, and methods for making and using the inventive compounds.

  本发明涉及式I的化合物，包括该化合物的药物组合物，以及制备和使用该创新化合物的方法。