5-Methyl-3-pyridineacetonitrile | 75279-59-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-Methyl-3-pyridineacetonitrile
• 英文别名: 2-(5-methylpyridin-3-yl)acetonitrile
• CAS: 75279-59-3
• 化学式: C₈H₈N₂
• 分子量: 132.16
• InChiKey: WUTDBSOUSJRTKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  36.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Dipyridyl-dihydropyrazolones and their use
  申请人：Flamme Ingo

  公开号：US20100035906A1

  公开（公告）日：2010-02-11

  The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.

  本申请涉及新型二吡啶基-二氢吡唑酮化合物，其制备方法，其用于治疗和/或预防疾病以及用于制备治疗和/或预防疾病的药物，特别是心血管和血液疾病、肾脏疾病和促进伤口愈合的药物。
• SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES
  申请人：FLAMME Ingo

  公开号：US20120322772A1

  公开（公告）日：2012-12-20

  The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.

  本申请涉及新型的二吡啶基-二氢吡唑酮化合物，其制备方法，用于治疗和/或预防疾病以及用于制备治疗和/或预防疾病的药物，特别是心血管疾病、血液学疾病和肾脏疾病，以及促进伤口愈合的用途。
• ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US20140038936A1

  公开（公告）日：2014-02-06

  The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

  本发明涉及用作PI3K抑制剂的化合物，特别是PI3Kγ的抑制剂。本发明还提供了包含该化合物的药学上可接受的组合物，并提供了使用该组合物治疗各种疾病、病况或障碍的方法。
• PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR
  申请人：Incyte Holdings Corporation

  公开号：EP3466953A1

  公开（公告）日：2019-04-10

  The present invention provides the use of 3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile in the preparation of a medicament for use in the treatment of graft versus host disease.

  本发明提供了 3-环戊基-3-[4-(7H-吡咯并[2,3-]嘧啶-4-基)-1H-吡唑-1-基]丙腈在制备用于治疗移植物抗宿主疾病的药物中的用途。
• Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
  申请人：Incyte Holdings Corporation

  公开号：EP2343299B9

  公开（公告）日：2017-03-08