Bergenin hydrate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Bergenin hydrate
• 英文别名: 3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydro-2H-pyrano[3,2-c]isochromen-6-one;hydrate
• 化学式: C14H18O10
• 分子量: 346.29
• InChiKey: QCWSXSAFDSGKAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.03
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  147
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• METHODS AND COMPOSITIONS FOR TREATING INFECTION
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US20150238473A1

  公开（公告）日：2015-08-27

  Provided herein are compositions and methods for treating or preventing infection.

  本文提供了用于治疗或预防感染的组合物和方法。
• Methods and compositions for treating infection
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US10004701B2

  公开（公告）日：2018-06-26

  Provided herein are compositions and methods for treating or preventing infection.

  本文提供了用于治疗或预防感染的组合物和方法。
• Triple drug combination (metformin, simvastatin, digoxin) for targeted treatment of pancreatic cancer
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US10813909B2

  公开（公告）日：2020-10-27

  A combination of three well-known and FDA approved compounds has been discovered to significantly suppress the proliferation of pancreatic cancer cells in clinically relevant models of pancreatic cancer. Embodiments of the invention include compositions of matter comprising a combination of agents such as metformin, simvastatin, and digoxin as well as methods of treating cancers using such agents. Illustrative methods include combining a population of pancreatic cancer cells with amounts of metformin, simvastatin, and digoxin sufficient to inhibit expression of BIRC5 protein in the population of pancreatic cancer cells, thereby inhibiting the growth of the population of pancreatic cancer cells.

  在临床相关的胰腺癌模型中，发现了三种众所周知并经美国食品及药物管理局批准的化合物的组合能显著抑制胰腺癌细胞的增殖。本发明的实施方案包括由二甲双胍、辛伐他汀和地高辛等药物组合而成的物质组合物，以及使用此类药物治疗癌症的方法。说明性方法包括将胰腺癌细胞群与足以抑制胰腺癌细胞群中BIRC5蛋白表达的二甲双胍、辛伐他汀和地高辛结合，从而抑制胰腺癌细胞群的生长。
• ANTIBIOTIC METHODS AND COMPOSITIONS FOR BACTERIA INFECTIONS
  申请人：The University of Chicago

  公开号：EP2916653A1

  公开（公告）日：2015-09-16
• METHODS AND COMPOUNDS FOR REDUCING INTRACELLULAR LIPID STORAGE
  申请人：Wu Sean

  公开号：US20130023488A1

  公开（公告）日：2013-01-24

  Compounds and compositions for reducing intracellular lipid accumulation in a cell are described herein. These compounds are useful for the treatment and prevention of lipid/glycogen disorders, as well as for the treatment and prevention of obesity. A high throughput screen for identifying compounds that reduce intracellular lipid accumulation in cells is also provided.