2-Fluoro-N-(4-fluorobenzyl)aniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Fluoro-N-(4-fluorobenzyl)aniline
• 英文别名: 2-fluoro-N-[(4-fluorophenyl)methyl]aniline
• 化学式: C₁₃H₁₁F₂N
• mdl: MFCD07579067
• 分子量: 219.23
• InChiKey: KQBMUYYUEWLGQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE<br/>[FR] INHIBITEURS DE HAT SPIROCYCLIQUES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ABBVIE INC

  公开号：WO2016044770A1

  公开（公告）日：2016-03-24

  Compounds having a structure of Formula (IX) or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1----Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.

  具有式（IX）的结构或其立体异构体、互变异构体或药学上可接受的盐的化合物，其中R1、R2a、R2b、R3a、R3b、R4a、R4b、Q1----Q2、R6、R7、A、B、W、x和y如本文所定义，并提供。还提供了包括这些化合物的药物组合物和通过给予这些化合物治疗各种HAT相关疾病或疾病，包括癌症的方法。
• SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE
  申请人：ABBVIE INC.

  公开号：US20160235716A1

  公开（公告）日：2016-08-18

  Compounds having a structure of Formula (IX): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R 1 , R 2a , R 2b , R 3a , R 3b , R 4a , R 4b , Q 1 - - - -Q 2 , R 6 , R 7 , A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.

  提供具有如下式（IX）的结构，或其立体异构体、互变异构体或药学上可接受的盐，其中R1、R2a、R2b、R3a、R3b、R4a、R4b、Q1- - - -Q2、R6、R7、A、B、W、x和y在此处定义并给出。还提供包括这些化合物的制药组合物和通过给予这些化合物的治疗各种HAT相关疾病或疾病，包括癌症的方法。
• A sustainable strategic approach for N-alkylation of amines with activation of alcohols triggered via a hydrogen auto-transfer reaction using a Pd(ii) complex: evidence for metal–ligand cooperativity
  作者：Virendra Kumar Chaudhary、Prashant Kukreti、Keshav Sharma、Kapil Kumar、Sain Singh、Sheela Kumari、Kaushik Ghosh

  DOI：10.1039/d4dt00864b

  日期：——

  new well-defined, air-stable, phosphine free palladium(II) [Pd(L)Cl] (1) catalyst. This catalyst was utilized for N-alkylation of amines and indole synthesis where H2O was found to be the by-product. A broad range of aromatic amines were alkylated using this homogeneous catalyst with a catalyst loading of 0.1 mol%. Greener aromatic and aliphatic primary alcohols were utilized and a hydrogen auto-transfer

  这项工作描述了一种新的结构明确、空气稳定、不含磷的钯( II )[Pd( L )Cl]( 1 )催化剂。该催化剂用于胺的N-烷基化和吲哚合成，其中发现 H 2 O 是副产物。使用这种催化剂负载量为 0.1 mol% 的均相催化剂对多种芳香胺进行烷基化。使用更环保的芳香族和脂肪族伯醇，并研究了通过金属-配体合作方法的氢自动转移策略。含抗组胺药分子三苯胺的前体以克级合成，以实现当前合成方法的大规模应用。进行了许多对照实验来研究可能的反应途径，这些实验的结果表明偶氮发色团在催化循环期间作为氢储存库。