1-[(4-Nitrophenyl)methyl] (2S)-1,2-azetidinedicarboxylate | 193269-77-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[(4-Nitrophenyl)methyl] (2S)-1,2-azetidinedicarboxylate
• 英文别名: (2S)-1-[(4-nitrophenyl)methoxycarbonyl]azetidine-2-carboxylic acid
• CAS: 193269-77-1
• 化学式: C12H12N2O6
• 分子量: 280.23
• InChiKey: HLCZVIYJGYUCBA-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• 1-METHYLCARBAPENEM DERIVATIVES
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0882728A1

  公开（公告）日：1998-12-09

  [Constitution] A 1-methylcarbapenem compound represented by the following formula (I): wherein R1 represents a hydrogen atom or a lower alkyl group; R2 represents a hydrogen atom or an ester residue; and A represents a substituted prolylaminopyrrolidin-1-ylcarbonyl, substituted aminoalkanoylaminopyrrolidin-1-ylcarbonyl, 1-hydroxy-2-(substituted aminoalkylpyrrolidin-1-ylcarbonyl)ethyl, 1-hydroxy-2-(substituted piperazin-1-ylcarbonyl)ethyl, 1-hydroxy-2-(substituted pyrrolidinylaminocarbonyl)ethyl or the like; or a pharmacologically acceptable salt thereof. [Advantages] 1-Methylcarbapenem compounds of the present invention have excellent antibacterial activity and they are useful agents for the prevention or treatment of infectious diseases.

  [组织结构］ 由下式(I)代表的1-甲基碳青霉烯类化合物： 其中 R1 代表氢原子或低级烷基；R2 代表氢原子或酯残基；A代表取代的脯氨酰氨基吡咯烷-1-基羰基、取代的氨基烷酰基氨基吡咯烷-1-基羰基、1-羟基-2-(取代的氨基烷基吡咯烷-1-基羰基)乙基、1-羟基-2-(取代的哌嗪-1-基羰基)乙基、1-羟基-2-(取代的吡咯烷氨基羰基)乙基或类似物；或其药理上可接受的盐。 优势 本发明的 1-甲基碳青霉烯化合物具有优异的抗菌活性，是预防或治疗传染性疾病的有效药物。
• Process for producing optically active N-substituted azetidine-2-carboxylic acid compound
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP0974670A2

  公开（公告）日：2000-01-26

  There is provided a process for producing an optically active N-substituted azetidine-2-carboxylic acid compound represented by the formula (2): by contacting a corresponding N-substituted azetidine-2-carboxylic acid ester of formula (2) with an enzyme derived from a microorganism selected from Arthrobacter SC-6-98-28 strain, Arthrobacter sp. ATCC21908 strain, Chromobacterium SC-YM-1 strain, and a mutant thereof. A process is also provided for preparing an optically active azetidine-2-carboxylic acid by eliminating the N-substituent of a N-substituted azetidine-2-carboxylic acid ester of formula (2).

  提供了一种生产具有光学活性的 N-取代氮杂环丁烷-2-羧酸化合物的工艺，该化合物由式（2）代表： 将相应的式(2)N-取代的氮杂环丁烷-2-羧酸酯与一种酶接触，该酶来源于一种微生物，该微生物选自节杆菌 SC-6-98-28 株、节杆菌 ATCC21908 株、色杆菌 SC-YM-1 株及其突变体。还提供了一种通过消除式（2）N-取代的氮杂环丁烷-2-羧酸酯的 N-取代基来制备光学活性氮杂环丁烷-2-羧酸的工艺。
• US6143554A
  申请人：——

  公开号：US6143554A

  公开（公告）日：2000-11-07
• US6090802A
  申请人：——

  公开号：US6090802A

  公开（公告）日：2000-07-18