Thiophene, 3-ethyl-4-isopropyl

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: Thiophene, 3-ethyl-4-isopropyl
• 英文别名: 3-ethyl-4-propan-2-ylthiophene
• 化学式: C₉H₁₄S
• 分子量: 154.27
• InChiKey: NIAMEMJAWKNOMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• PHOSPHONIUM ION CHANNEL BLOCKERS AND METHODS FOR USE
  申请人：Nocion Therapeutics, Inc.

  公开号：US20210128589A1

  公开（公告）日：2021-05-06

  The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

  本发明提供了式(I)的化合物，或其药用可接受的盐： 本发明的化合物、组合物、方法和试剂盒可用于治疗疼痛、瘙痒和神经性炎症。
• Charged ion channel blockers and methods for use
  申请人：Nocion Therapeutics, Inc.

  公开号：US10842798B1

  公开（公告）日：2020-11-24

  The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

  该发明提供了公式(I)的化合物或其药学上可接受的盐：该发明的化合物、组合物、方法和试剂盒对于治疗疼痛、瘙痒和神经源性炎症是有用的。
• [EN] VACCINE ADJUVANTS AND METHODS OF SYNTHESIZING AND USING THE SAME<br/>[FR] ADJUVANTS DE VACCINS ET LEURS PROCÉDÉS DE SYNTHÈSE ET D'UTILISATION
  申请人：AMYRIS INC

  公开号：WO2022011031A1

  公开（公告）日：2022-01-13

  The disclosure provides compounds useful as adjuvants in vaccines, as well as methods of synthesizing such compounds and methods of using such compounds in the formulation of a vaccine. The disclosure also features methods of administering such vaccines to a subject (e.g., a mammalian subject, such as a human) in order to treat or prevent one or more diseases, such as a disease caused by a viral or bacterial infection.

  本披露提供了化合物，可用作疫苗佐剂，以及合成此类化合物的方法和使用此类化合物制备疫苗的方法。本披露还提供了将这种疫苗用于治疗或预防一种或多种疾病的方法（例如，由病毒或细菌感染引起的疾病），并将这种疫苗用于受试者（例如，哺乳动物受试者，例如人类）的方法。
• Small molecule inhibitors of TRPA1
  申请人：B.R.A.I.N. Biotechnology Research and Information Network AG

  公开号：US10000438B2

  公开（公告）日：2018-06-19

  The present invention relates to the use of compounds which are capable of attenuating skin irritation when they are applied to the skin. Skin irritation can be caused, inter alia, by ingredients of cosmetic or pharmaceutical compositions and/or environmental irritants. In particular, the present invention relates to compounds having the property of antagonizing the activation of the transient receptor potential (TRP) ankyrin 1 (TRPA1) ion channel and the use of said compounds as soothing agents. Such compounds can be used in many fields, particularly in personal-care products, cosmetics, textile and packaging products, pharmaceutical compositions, medical devices, and foodstuffs. The present invention further relates to products and/or pharmaceutical compositions containing said compounds. The present invention also relates to the use of the compounds described herein for the modulation of the taste of a food product.

  本发明涉及化合物的使用，当这些化合物用于皮肤时，能够减轻对皮肤的刺激。皮肤刺激可由化妆品或药物组合物的成分和/或环境刺激物等引起。本发明尤其涉及具有拮抗瞬时受体电位（TRP）ankin 1（TRPA1）离子通道活化特性的化合物，以及将上述化合物用作舒缓剂。此类化合物可用于许多领域，特别是个人护理产品、化妆品、纺织品和包装产品、药物组合物、医疗器械和食品。本发明还涉及含有上述化合物的产品和/或药物组合物。本发明还涉及本文所述化合物在调节食品口味方面的用途。
• Macrocyclic ligands with pendant chelating moieties and complexes thereof
  申请人：LUMIPHORE, INC.

  公开号：US10239878B2

  公开（公告）日：2019-03-26

  The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.

  本发明涉及配体和金属离子与配体的络合物，可用于各种应用，包括治疗和诊断应用。