11-Hydroxyaporphin | 740744-77-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 阿朴菲
• 英文名称: 11-Hydroxyaporphin
• 英文别名: 6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol；11-Hydroxyaporphine；6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol
• CAS: 740744-77-8
• 化学式: C₁₇H₁₇NO
• 分子量: 251.328
• InChiKey: PCGXWSCASZVBJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] 2-ALKOXY-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE 2-ALCOXY-11-HYDROXYAPORPHINE ET LEURS UTILISATIONS
  申请人：MCLEAN HOSPITAL CORP

  公开号：WO2011130530A1

  公开（公告）日：2011-10-20

  The invention features 2-alkoxy-l l-hydroxyaporphine derivatives that selectively bind D2high receptors. The compounds are useful for imaging D2high receptors and for the treatment of diseases, such as Parkinson's disease, sexual dysfunction, and depressive disorders.

  这项发明涉及选择性结合D2高亲和力受体的2-烷氧基-1-羟基吖啶衍生物。这些化合物可用于成像D2高亲和力受体以及用于治疗帕金森病、性功能障碍和抑郁症等疾病。
• 2-alkoxy-11-hydroxyaporphine derivatives and uses thereof
  申请人：The McLean Hospital Corporation

  公开号：US10081600B2

  公开（公告）日：2018-09-25

  The invention features 2-alkoxy-11-hydroxyaporphine derivatives that selectively bind D2high receptors. The compounds are useful for imaging D2high receptors and for the treatment of diseases, such as Parkinson's disease, sexual dysfunction, and depressive disorders.

  本发明具有选择性结合 D2high 受体的 2-烷氧基-11-羟基吗啡衍生物。这些化合物可用于 D2high 受体成像和疾病治疗，如帕金森病、性功能障碍和抑郁症。
• Glycoside and orthoester glycoside derivatives of apomorphine, analogs, and uses thereof
  申请人：Holick Michael

  公开号：US20060004190A1

  公开（公告）日：2006-01-05

  Disclosed are glycoside and orthoester glycoside derivatives of apomorphine and analogs thereof to treat conditions and diseasessuch as erectile dysfunction.

  所公开的是阿朴吗啡的糖苷和原酯糖苷衍生物及其类似物，用于治疗勃起功能障碍等病症。
• R(-)-11-hydroxyaporphine derivatives and uses thereof
  申请人：Neumeyer L. John

  公开号：US20060040900A1

  公开（公告）日：2006-02-23

  The invention features derivatives of R(—)-11-hydroxyaporphines and methods of treating Parkinson's disease, sexual dysfunction, and depressive disorders therewith.

  本发明的特点是 R(-)-11-羟基阿扑啡的衍生物以及用其治疗帕金森病、性功能障碍和抑郁障碍的方法。
• [EN] R(-)-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF<br/>[FR] DERIVES DE R(<supplemental>20051222</supplemental>GAO Y ET AL: "Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine.", J MED CHEM., vol. 31, 1988, pages 1392 - 1396, XP002992383GAO Y ET ALSynthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine.J MED CHEM.19883113921396XXGRANCHELLI FE ET AL: "Aporphines. 23. Normorphothebaine derivatives: Synthesis of an aporphine nitrogen mustard.", J ORG CHEM., vol. 42, 1977, pages 2014 - 2017, XP002992384GRANCHELLI FE ET ALAporphines. 23. Normorphothebaine derivatives: Synthesis of an aporphine nitrogen mustard.J ORG CHEM.19774220142017XX
  申请人：MCLEAN HOSPITAL CORP

  公开号：WO2005099702A3

  公开（公告）日：2005-12-22