5-(2-Nitrophenyl)-1,3,4-thiadiazole-2-sulfonyl chloride | 835622-69-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(2-Nitrophenyl)-1,3,4-thiadiazole-2-sulfonyl chloride
• CAS: 835622-69-0
• 化学式: C8H4ClN3O4S2
• 分子量: 305.7
• InChiKey: QAOLSCPWPUIXSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  142
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-beta-Aminoethyl-gly-oet 2hcl 、 5-(2-Nitrophenyl)-1,3,4-thiadiazole-2-sulfonyl chloride 生成 N-{2-[5-(2-nitrophenyl)-1,3,4-thiadiazole-2-sulfonylamino]-ethyl}-glycine ethyl ester
  参考文献：
  名称：

  PNA monomer and precursor

  摘要：

  该应用程序涉及通式（I）的单体，用于制备PNA（肽核酸）寡聚体，并提供了预定义序列PNA寡聚体和随机序列PNA寡聚体的合成方法： 其中E是硫或氧；J是氮或C—R′；R1、R′独立地为H、卤素、烷基、硝基、腈、烷氧基、卤代烷基、卤代烷氧基或具有以下一般式之一的功能基： 其中A1、A2、A3、A4、A5独立地选自H、卤素（如F、Cl、Br或I）、CF3、烷基，优选为C1-C4烷基、硝基、腈、烷氧基，优选为C1-C4烷氧基、卤代（如F、Cl、Br和I）烷基，优选为卤代的C1-C4烷基、卤代（如F、Cl、Br和I）烷氧基，优选为卤代的C1-C4烷氧基、苯基和卤代（如F、Cl、Br和I）苯基；R2为H或天然或非天然α-氨基酸的保护或未保护侧链；B为天然或非天然核苷碱，其中当所述核苷碱具有外环氨基功能时，所述功能由对酸敏感但在巯基存在下对弱至中等碱稳定的保护基保护。

  公开号：

  US20050026930A1

文献信息

• [EN] PNA MONOMER AND PRECURSOR<br/>[FR] MONOMÈRE DE PROTÉINE PNA ET PRÉCURSEUR
  申请人：PANAGENE INC

  公开号：WO2005009998A1

  公开（公告）日：2005-02-03

  This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers,wherein E is sulfur or oxygen; J is nitrogen or C-R'; R1, R' is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy or a functional group having one of following general formulae (A, B) wherein A1, A2, A3, A4, A5, is independently selected from H, halogen such as F, Cl, Br or I, CF3, alkyl, preferably C1,-C4 alkyl, nitro, nitrile, alkoxy, preferably C1,-C4 alkoxy, halogenated (such as F, Cl, Br and I) alkyl, preferably halogenated C1-C4 alkyl, halogenated (such as F, Cl, Br and I) alkoxy, preferably halogenated Ci-C4 alkoxy, phenyl, and halogenated (such as F, Cl, Br and I) phenyl; R2 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

  该应用涉及通用式(I)的单体，用于制备PNA（肽核酸）寡聚体，并提供了合成预定义序列PNA寡聚体和随机序列PNA寡聚体的方法，其中E为硫或氧；J为氮或C-R'；R1、R'独立取H、卤素、烷基、硝基、腈基、烷氧基、卤代烷基、卤代烷氧基或具有以下通用式(A、B)之一的功能基团，其中A1、A2、A3、A4、A5独立选择自H、氟、氯、溴或碘等卤素、三氟甲基、烷基，优选C1-C4烷基、硝基、腈基、烷氧基，优选C1-C4烷氧基、卤代（如氟、氯、溴和碘）烷基，优选卤代C1-C4烷基、卤代（如氟、氯、溴和碘）烷氧基，优选卤代C1-C4烷氧基，苯基和卤代（如氟、氯、溴和碘）苯基；R2为H或天然或非天然α-氨基酸的保护或未保护侧链；B为天然或非天然核碱基，其中当所述核碱基具有外环氨基功能时，所述功能由对酸敏感但在巯基存在的弱到中等碱存在下稳定的保护基团保护。
• PNA MONOMER AND PRECURSOR
  申请人：Panagene Inc.

  公开号：EP1651642A1

  公开（公告）日：2006-05-03
• EP1651642A4
  申请人：——

  公开号：EP1651642A4

  公开（公告）日：2006-11-29
• US7211668B2
  申请人：——

  公开号：US7211668B2

  公开（公告）日：2007-05-01
• PNA monomer and precursor
  申请人：Kim Kee Sung

  公开号：US20050026930A1

  公开（公告）日：2005-02-03

  This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is sulfur or oxygen; J is nitrogen or C—R′; R1, R′ is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy or a functional group having one of following general formulae: wherein A 1 , A 2 , A 3 , A 4 , A 5 , is independently selected from H, halogen such as F, Cl, Br or I, CF 3 , alkyl, preferably C 1 -C 4 alkyl, nitro, nitrile, alkoxy, preferably C 1 -C 4 alkoxy, halogenated (such as F, Cl, Br and I) alkyl, preferably halogenated C 1 -C 4 alkyl, halogenated (such as F, Cl, Br and I) alkoxy, preferably halogenated C 1 -C 4 alkoxy, phenyl, and halogenated (such as F, Cl, Br and I phenyl; R2 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

  该应用程序涉及通式（I）的单体，用于制备PNA（肽核酸）寡聚体，并提供了预定义序列PNA寡聚体和随机序列PNA寡聚体的合成方法： 其中E是硫或氧；J是氮或C—R′；R1、R′独立地为H、卤素、烷基、硝基、腈、烷氧基、卤代烷基、卤代烷氧基或具有以下一般式之一的功能基： 其中A1、A2、A3、A4、A5独立地选自H、卤素（如F、Cl、Br或I）、CF3、烷基，优选为C1-C4烷基、硝基、腈、烷氧基，优选为C1-C4烷氧基、卤代（如F、Cl、Br和I）烷基，优选为卤代的C1-C4烷基、卤代（如F、Cl、Br和I）烷氧基，优选为卤代的C1-C4烷氧基、苯基和卤代（如F、Cl、Br和I）苯基；R2为H或天然或非天然α-氨基酸的保护或未保护侧链；B为天然或非天然核苷碱，其中当所述核苷碱具有外环氨基功能时，所述功能由对酸敏感但在巯基存在下对弱至中等碱稳定的保护基保护。